Evidence map›Paper›PMID 40895851›Full record

ArticleCureus2025

Managing Brugada Syndrome in a Private Dental Practice: A Structured Case-Based Review.

Francesco Valente, Giacomo Gerboni, Pierluigi Valente, Lapo Sbrenna, Andrea Sbrenna

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Francesco ValenteOral Implantology, San Damiano Dental Clinic, Rome, ITA.
Giacomo GerboniOral Medicine, San Damiano Dental Clinic, Rome, ITA.
Pierluigi ValenteDentistry, School of Dentistry, Vita-Salute San Raffaele University, Milano, ITA.
Lapo SbrennaDentistry, School of Dentistry, University of Bologna, Bologna, ITA.
Andrea SbrennaPrivate Practice, Humanis Dental Center, Perugia, ITA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brugada syndrome (BrS) is a rare inherited cardiac condition associated with a heightened risk of malignant arrhythmias, particularly during exposure to various pharmacological agents, including certain local anesthetics with sodium channel-blocking properties. This condition often generates significant concern among dental professionals, as the routine use of local anesthetics raises uncertainty about safety protocols and perceived medico-legal risks, frequently leading to patient refusal. The result is a silent yet systematic exclusion of these patients from standard pathways of care, with implications that extend beyond the clinical domain to encompass ethical, deontological, and social dimensions. We report the case of a 29-year-old male with BrS and a subcutaneous implantable cardioverter-defibrillator who underwent a conservative restorative dental procedure in a private outpatient clinic. Given the potential risk of arrhythmia during anesthetic infiltration, 4% articaine with epinephrine 1:100,000 was administered slowly and at the minimum effective dose under continuous cardiologic supervision, with real-time ECG and vital sign monitoring initiated prior to injection and maintained throughout the session. The treatment was completed uneventfully, with no ECG abnormalities observed. While limited to a single observation, this case illustrates that, under carefully controlled conditions and with appropriate precautions, outpatient dental management of patients with BrS may be considered a viable option in selected cases. This report includes a brief review of the literature and a focused discussion on the medico-legal implications to contextualize this case and support safe, ethical, and reproducible clinical decision-making in similar outpatient settings.

Indexed as

adrenalinearticainebrugadabrugada dental carebrugada syndromedental anesthesiaepinephrinelidocaineregional anesthetics

Identifiers

PMID40895851
PMCPMC12393005

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.