ArticleCureus2025
Managing Brugada Syndrome in a Private Dental Practice: A Structured Case-Based Review.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Dental drugs with proarrhythmic risk in patients with Brugada syndrome: precaution instructions for practices in the field of orofacial pain.Frontiers in cardiovascular medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brugada syndrome (BrS) is a rare inherited cardiac condition associated with a heightened risk of malignant arrhythmias, particularly during exposure to various pharmacological agents, including certain local anesthetics with sodium channel-blocking properties. This condition often generates significant concern among dental professionals, as the routine use of local anesthetics raises uncertainty about safety protocols and perceived medico-legal risks, frequently leading to patient refusal. The result is a silent yet systematic exclusion of these patients from standard pathways of care, with implications that extend beyond the clinical domain to encompass ethical, deontological, and social dimensions. We report the case of a 29-year-old male with BrS and a subcutaneous implantable cardioverter-defibrillator who underwent a conservative restorative dental procedure in a private outpatient clinic. Given the potential risk of arrhythmia during anesthetic infiltration, 4% articaine with epinephrine 1:100,000 was administered slowly and at the minimum effective dose under continuous cardiologic supervision, with real-time ECG and vital sign monitoring initiated prior to injection and maintained throughout the session. The treatment was completed uneventfully, with no ECG abnormalities observed. While limited to a single observation, this case illustrates that, under carefully controlled conditions and with appropriate precautions, outpatient dental management of patients with BrS may be considered a viable option in selected cases. This report includes a brief review of the literature and a focused discussion on the medico-legal implications to contextualize this case and support safe, ethical, and reproducible clinical decision-making in similar outpatient settings.
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Registered trials
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