ArticleBiological psychiatry global open science2025
Neurocognitive Biotypes of Risk and Resilience for Mood Disorders in Adolescents: Insights From Behavioral and Graph-Theoretic Network Markers.
Article in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- High perceived energy: exploring distinct patterns of energetic and cognitive functioning in older adults.Frontiers in psychiatry · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Background: Adolescence is a developmental period of increased prevalence of mood disorders, but identifying adolescents who are at risk for or resilient to mood pathology remains a clinical challenge. In the current study, we addressed this challenge by evaluating multidimensional profiles of neurocognitive functioning (biotypes) that may confer vulnerability or protect against psychopathology. Biotypes were derived from neurocognitive data and identified as being resilient or high risk based on their association with future symptoms. Methods: Adolescents ( Results: Biotype 1 (high executive functions, balanced integration/segregation of functional brain networks) was resilient: adolescents in this biotype reported low symptom variability, even under heightened life stress. Adolescents in biotype 2 (poor executive functions, low frontoparietal modularity) reported higher variability in symptoms of mania/hypomania overall. Adolescents in biotype 3 (mixed reward sensitivity, high overall network modularity) reported high variability in symptoms of anhedonia and mania/hypomania, if also reporting heightened life stress. Adolescents in biotype 4 (blunted reward decision processing, hyperconnected networks) reported high variability in symptoms of anhedonia, if also reporting heightened life stress. Conclusions: Neurocognitive biotypes may identify adolescents who are resilient to, or at risk for, mood pathology.
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Registered trials
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