ArticleJournal of clinical & translational endocrinology2025
Relationships of triglyceride-glucose index and body mass index with 5-year all-cause mortality in patients with diabetes and comorbid hypertension: Evidence from two prospective cohort studies.
Article in Journal of clinical & translational endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Head-to-head comparison of fasting-insulin-based versus non-insulin-based insulin resistance surrogates for predicting all-cause and cardiovascular mortality in hypertensive adults across the glycemic continuum: a prospective cohort study.Cardiovascular diabetology · 2026Article
- Triglyceride-glucose index and mortality in critically ill patients with cardiovascular-kidney-metabolic syndrome stage 4.Cardiovascular diabetology · 2026Article
- A novel risk prediction model incorporating triglyceride-glucose-body mass index for in-hospital mortality in hypertensive patients with HFmrEF.Lipids in health and disease · 2026Article
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15 authors.
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Abstract
Aims: To characterize the complex relationships of body mass index (BMI) and triglyceride-glucose index (TyG) with 5-year all-cause mortality in patients with diabetes mellitus and comorbid hypertension. Methods: Overall, 5,728 patients from the 1999-2014 US National Health and Nutrition Examination Survey (NHANES) cycles and 3,456 from the 2005-2010 China Kailuan cycles were included. TyG was calculated as the logarithmic product of the fasting triglyceride and glucose concentrations. Results: The prevalence of 5-year all-cause mortality was 8.4 % in the NHANES population and 9.2 % in the Kailuan cohort. TyG mediated the association between BMI and all-cause mortality, being responsible for 38.4 % in the NHANES database and 41.6 % in the Kailuan cohort. Significant multiplicative effects were identified between TyG and BMI, which were closer for patients with high BMI. When stratified by BMI and TyG, high-risk subgroups were identified and had higher risks of all-cause mortality than the intermediate- and low-risk subgroups (both log-rank Conclusions: TyG mediated a considerable proportion of the effect of BMI on all-cause mortality in patients with diabetes and hypertension. The combination of BMI and TyG could be useful for the risk stratification of all-cause mortality. Measures aimed at weight loss might reduce the all-cause mortality risk associated with insulin resistance.
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