Evidence map›Paper›PMID 40895812›Full record

ArticlePolymer2025

Synthesis of polymer-clindamycin conjugates through lipase-catalyzed esterification and RAFT polymerization.

Masoud Zamani, Dayron M Leyva Rodriguez, Ziwen Zhang, Camila Sabatini, Mark T Swihart, Michelle B Visser, Chong Cheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Masoud ZamaniDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA.ORCID 0000-0003-3420-8443
Dayron M Leyva RodriguezDepartment of Oral Biology, University at Buffalo, The State University of New York, Buffalo, NY, 14214, USA.ORCID 0000-0003-0904-4387
Ziwen ZhangDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA.
Camila SabatiniDepartment of Restorative Dentistry, University at Buffalo, The State University of New York, Buffalo, NY, 14214, USA.
Mark T SwihartDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA.ORCID 0000-0002-9652-687X
Michelle B VisserDepartment of Oral Biology, University at Buffalo, The State University of New York, Buffalo, NY, 14214, USA.ORCID 0000-0002-6467-3314
Chong ChengDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA.

Funding

Enabling Access to Cutting-Edge Biomedical and Behavioral ScienceR25GM095459 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DUBOCOVICH, MARGARITA L · 2012 to 2021
$4.4M
Mentoring For Success: Teaching Faculty Fundamental Skills For Attracting, Admitting and Developing StudentsT32GM144920 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Margarita L Dubocovich · 2022 to 2026
$3.1M
Polymer-Antibiotic Conjugates as Antibacterial Additives for Dental ResinsR21DE028437 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI CHENG, CHONG, SABATINI, CAMILA · 2019 to 2020
$434k
NIDCR NIH HHS R21 DE028437NIGMS NIH HHS R25 GM095459NIGMS NIH HHS T32 GM144920
6 · The paper itself

Abstract

Relative to free antibiotics, polymer-antibiotic conjugates (PACs) can possess modified solubility, sustained release behavior, and prolonged bioactivity in biological systems. As one of the most potent and ubiquitous antibiotics, clindamycin (Clin) has broad-spectrum antibiotic activity with versatile medical applications. However, polymer-Clin conjugates have not been reported yet. This can be partly ascribed to the difficulties in selective modification of Clin which possesses multiple reactive hydroxyl groups. In this study, we employed immobilized lipase as a bio-based catalyst for the facile and highly regioselective synthesis of a methacrylic-functionalized monomer-Clin conjugate via a one-step reaction. Reversible addition fragmentation chain transfer (RAFT) polymerization was then employed to synthesize copolymers of the monomer-Clin conjugate with 2-hydroxymethyl methacrylate or 3-[(3-acrylamidopropyl) dimethylammonio]propanoate to achieve water-insoluble and water-soluble Clin-containing PACs, respectively. These PACs possessed well-defined structures with high Clin content (33-46 wt%), as confirmed by

Indexed as

ClindamycinLipase-catalyzed esterificationPolymer-antibiotic conjugatePolymer-drug conjugateRAFT polymerization

Identifiers

PMID40895812
PMCPMC12392158

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.