ArticleRSC advances2025
Tetrazole derivatives synthesis
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
Tetrazoles are highly significant in pharmaceuticals, drug delivery, and anticancer treatments. In this work, the development of a highly effective nanocatalyst, which was synthesized by functionalizing nanodiamonds (NDs) substrate with folic acid (FA) and stabilizing Cu(ii) on the nanocomposite. The ND@FA-Cu(ii) nanocatalyst has demonstrated superior thermal stability, non-toxicity, little catalyst consumption, and reusability (up to five cycles), rendering it both cost-effective and environmentally sustainable. The catalytic efficacy of ND@FA-Cu(ii) was assessed in the production of 1H-tetrazole derivatives employing two methodologies. A one-pot synthesis using malononitrile, sodium azide, and benzyl alcohol (oxidized in acetonitrile) effectively yielded 5-substituted 1H-tetrazoles. The second strategy involved the synthesis of 1H-tetrazoles from benzaldehyde, malononitrile, and sodium azide in ethanol under mild conditions
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Registered trials
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