Evidence map›Paper›PMID 40895650›Full record

ReviewCureus2025

Imaging in Hemophagocytic Lymphohistiocytosis: A Comprehensive Pictorial Essay.

Caleb Bhatnagar, Emad Allam, Mathew Illimoottil, Sarah Illimoottil, Eric Errampalli, Sriya Kosaraju

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Caleb BhatnagarRadiology, Loyola University Medical Center, Maywood, USA.
Emad AllamRadiology, Loyola University Medical Center, Maywood, USA.
Mathew IllimoottilRadiology, University of Missouri Kansas City School of Medicine, Kansas City, USA.
Sarah IllimoottilRadiology, University of Missouri Kansas City School of Medicine, Kansas City, USA.
Eric ErrampalliInternal Medicine, University of Missouri Kansas City School of Medicine, Kansas City, USA.
Sriya KosarajuRadiology, University of Missouri Kansas City School of Medicine, Kansas City, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a rare but life-threatening condition characterized by excessive immune activation, resulting in severe systemic inflammation and multiorgan failure. This pictorial essay presents an overview of HLH imaging findings, accompanied by a discussion of pathophysiology, diagnosis, and treatment approaches. Imaging is crucial in diagnosing and monitoring HLH by identifying key features, such as splenomegaly, lymphadenopathy, and central nervous system (CNS) involvement. While the imaging findings associated with HLH are nonspecific and do not constitute part of the diagnostic criteria for HLH, they are helpful in the diagnostic process and can offer valuable insights into the extent of organ involvement and disease progression, guiding timely interventions. This article emphasizes the importance of recognizing imaging patterns associated with HLH for early diagnosis and effective management.

Indexed as

epstein barr virus (ebv)familial hlh (fhl)hemophagocytic lymphohistiocytosis (hlh)secondary cnssecondary hemophagocytic lymphohistiocytosis (hlh)

Identifiers

PMID40895650
PMCPMC12399025

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.