Evidence map›Paper›PMID 40895560›Full record

ArticleFrontiers in immunology2025

Irisin alleviated sepsis via enhancing macrophage phagocytosis and reducing inflammation levels.

Zeen Gong, Yunyan Ji, Haiyang Wu, Linli Xue, Xiuju Yu, Xiaomao Luo, Yi Yan, Jiayin Lu, Juan Wang, Yanjun Dong and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zeen GongCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, Shanxi, China.
Yunyan JiCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, Shanxi, China.
Haiyang WuCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, Shanxi, China.
Linli XueCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, Shanxi, China.
Xiuju YuCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, Shanxi, China.
Xiaomao LuoCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, Shanxi, China.
Yi YanCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, Shanxi, China.
Jiayin LuCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, Shanxi, China.
Juan WangDepartment of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yanjun DongCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Haidong WangCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, Shanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The treatment of sepsis relies on antibiotics following infection; however, the emergence of resistant bacteria necessitates the development of new therapeutic agents. Irisin has been shown to alleviate symptoms in septic mice, although its mechanism of action remains unclear. Our aim was to determine the mechanism by which irisin alleviates sepsis. Methods: In this study, septicemia was induced in mice using Results: Conclusions: Irisin improves splenic macrophage phagocytosis and reduces macrophage inflammation, thereby mitigating sepsis. Irisin holds potential as a therapeutic agent for sepsis treatment.

Indexed as

FibronectinsMacrophagesPhagocytosisSepsisAnimalsDisease Models, AnimalEscherichia coliEscherichia coli InfectionsInflammationMaleMiceRAW 264.7 CellsStaphylococcal InfectionsStaphylococcus aureusFibronectinsFNDC5 protein, mouseinflammationirisinmacrophagephagocytosissepsis

Identifiers

PMID40895560
PMCPMC12394160

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.