Evidence map›Paper›PMID 40895555›Full record

ArticleFrontiers in immunology2025

Passive physical barrier modulates UVB-induced METosis-related MPO expression and activity, 25-hydroxyvitamin D3-1alpha-hydroxylase, and the shift of tissue-resident macrophages toward M1-associated iNOS.

Farah Sara Meterfi, Souad Zoudji, Nour Elhouda Bendjeffel, Rabia Messali, Fadila Boudjelal, Chahrazed El Mezouar, Nawal Brikci Nigassa, Zineb Mekkaoui, Slimane Brikhou, Franck Jd Mennechet and 4 more

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Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Farah Sara MeterfiLaboratory of Applied Molecular Biology and Immunology, University of Tlemcen, Tlemcen, Algeria.
Souad ZoudjiLaboratory of Applied Molecular Biology and Immunology, University of Tlemcen, Tlemcen, Algeria.
Nour Elhouda BendjeffelLaboratory of Applied Molecular Biology and Immunology, University of Tlemcen, Tlemcen, Algeria.
Rabia MessaliLaboratory of Applied Molecular Biology and Immunology, University of Tlemcen, Tlemcen, Algeria.
Fadila BoudjelalLaboratory of Applied Molecular Biology and Immunology, University of Tlemcen, Tlemcen, Algeria.
Chahrazed El MezouarLaboratory of Applied Molecular Biology and Immunology, University of Tlemcen, Tlemcen, Algeria.
Nawal Brikci NigassaLaboratory of Applied Molecular Biology and Immunology, University of Tlemcen, Tlemcen, Algeria.
Zineb MekkaouiLaboratory of Applied Molecular Biology and Immunology, University of Tlemcen, Tlemcen, Algeria.
Slimane BrikhouLaboratory of Applied Molecular Biology and Immunology, University of Tlemcen, Tlemcen, Algeria.
Franck Jd MennechetPathogenesis and Control of Chronic and Emerging Infections, The Institut National de la Santé et de la Recherche Médicale (INSERM) U1058, University of Montpellier, Etablissement Français du Sang, Antilles University, Montpellier, France.
Chafia Touil-BoukoffaLaboratory of Applied Molecular Biology and Immunology, University of Tlemcen, Tlemcen, Algeria.
Xin LiShenzhen Key Laboratory of Viral Oncology, The Clinical Innovation and Research Center (CIRC), Shenzhen Hospital, Southern Medical University, Shenzhen, China.
Abdelouahab BellouLaboratory of Applied Molecular Biology and Immunology, University of Tlemcen, Tlemcen, Algeria.
Mourad AribiLaboratory of Applied Molecular Biology and Immunology, University of Tlemcen, Tlemcen, Algeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study investigated the role of UVB radiation and the influence of a simulated passive barrier on the enzymatic conversion of 25-hydroxyvitamin D3 (25(OH)D Methods: Murine peritoneal tissue-resident macrophages (PRMφs) were exposed to three conditions: (1) Baseline (Control group), with no light exposure; (2) UVB+/RF- group, exposed to UVB rays without passive barrier simulation; (3) UVB+/RF+ group, UVB exposure with a thin layer of rat fur to mimic the passive barrier on the skin. Results: UVB exposure did not significantly alter 25OHD Conclusions: UVB exposure enhances tissue-resident macrophage function in a preclinical rat model, increasing respiratory burst, phagocytosis, and M1-like polarization. The simulated barrier modulates these effects, notably by reducing MPO expression and METosis-related activity, which suggests a potential attenuation of excessive inflammation. These findings provide valuable insights relevant to human immune modulation and support further translational research. Future studies should investigate the role of circadian rhythms and other cell types in UVB- and vitamin D-mediated immune modulation.

Indexed as

25-Hydroxyvitamin D3 1-alpha-HydroxylaseMacrophagesMacrophages, PeritonealNitric Oxide Synthase Type IIPeroxidaseUltraviolet RaysAnimalsMaleMiceNitric OxidePhagocytosisRats25-Hydroxyvitamin D3 1-alpha-HydroxylaseNitric OxideNitric Oxide Synthase Type IINos2 protein, mousePeroxidase25-hydroxyvitamin D3-1alpha-hydroxylaseM1 macrophage-associated iNOS activityMETosis-related MPO expression and activityperitoneal tissue-resident macrophagesphysical barrier simulationUVB exposure

Identifiers

PMID40895555
PMCPMC12390812

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