ArticleFrontiers in immunology2025
Abnormal lipid metabolism and atherosclerosis: a new perspective on organelle function regulation and ferroptosis.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Immunopathogenesis of accelerated atherosclerosis in systemic lupus erythematosus: from innate and adaptive dysregulation to clinical implications.Frontiers in immunology · 2026Review
- Association between atherogenic index of plasma and post-stroke epilepsy within one year in patients with acute ischemic stroke: a retrospective cohort study.Frontiers in neurologyArticle
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Authors and funding
13 authors.
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Abstract
Background: Atherosclerosis (AS), characterized by lipid accumulation, contributes significantly to global cardiovascular morbidity. Ferroptosis, an iron-dependent form of cell death triggered by lipid peroxidation, is emerging as a critical player in AS progression. Therefore, our study seeks to elucidate the intricate mechanisms of ferroptosis within the lipid metabolism pathway in AS. Methods: Differentially expressed genes were identified from the GSE100927 dataset, subsequently isolating AS lipid metabolism-related ferroptosis genes (ASLMRFeGs). Unsupervised cluster analysis was performed on AS samples to identify molecular clusters. WGCNA was performed to uncover module Hub genes. Multiple machine learning models (LASSO, SVM-RFE, RF) were applied to screen Hub genes. Experimental validation was performed by ox-LDL-induced HUVECs and RAW 264.7 cells. Single-cell data analyzes the gene structure and gene expression status of individual cells. Results: Six ASLMRFeGs (CTSB, CYBB, DPP4, HILPDA, HMOX1, IL1B) alter the immune microenvironment in AS. AS samples were stratified into two molecular clusters, exhibiting significant variations in inflammation and immune responses. Enrichment analysis of the 225 module Hub genes showed close association with inflammation, immune responses, cytoskeleton organization, and various organelles. Machine learning identified four candidate Hub genes (TYROBP, CSF1R, LCP2, C1QA). Conclusion: In AS, abnormal lipid metabolism may drive ferroptosis via key regulatory genes (CYBB, HMOX1, IL1B, TYROBP, CSF1R), while also reshaping the immune microenvironment, potentially through the modulation of organelle function.
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