ArticleFrontiers in microbiology2025
Long-term neurocognitive outcomes of SARS-CoV-2 infection in a hamster model.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Translational insights into Long-COVID: evaluation of preclinical animal models along the lung-brain-immune axis with focus on Golden Syrian Hamsters.Journal of neuroinflammation · 2026Review
- COVID-19-related inflammation of the placenta impedes fetal development in pregnant hamsters.Nature communications · 2026Article
- Persistent neurological and behavioral alterations after SARS-CoV-2 infection in an optimized K18-hACE2 mouse model.Frontiers in microbiology · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Post-COVID-19 condition (PCC) is a long-lasting, multisystemic syndrome affecting approximately 30% of individuals after acute COVID-19, with neurological symptoms among the most prevalent and debilitating. Despite its substantial global health impact, the biological mechanisms underlying PCC remain poorly understood, underscoring the need for validated animal models. Methods: To address this, we conducted a longitudinal study using the golden Syrian hamster model, integrating virological, immunological, histopathological, and behavioral analyses from the acute phase to 60 days post-inoculation. Results: Our results showed persistent viral RNA, prolonged immune dysregulation, and behavioral changes that mirrored key features of human PCC. Discussion: Although fully reproducing PCC in animal models is inherently challenging due to its complex and heterogeneous presentation in humans, the use of complementary models with distinct phenotypes is essential for elucidating its pathophysiology. These results aim to contribute valuable insights into the biological basis of PCC and support the development of targeted preventative and therapeutic strategies.
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Registered trials
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