Evidence map›Paper›PMID 40895433›Full record

ReviewFrontiers in physiology2025

Advancements in macrophage research for cardiovascular disease.

Meiling Cao, Yu Sun, Xinyue Zhang, Jiahui Zou, Mingyue Shi, Lei Li, Hongkun Jiang

Abstract readReview
In one paragraph

Review in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meiling Cao *Department of Neonatology, The First Hospital of China Medical University, Shenyang, China.
Yu Sun *Department of Pediatrics, The First Hospital of China Medical University, Shenyang, China.
Xinyue Zhang *Department of Pediatrics, The First Hospital of China Medical University, Shenyang, China.
Jiahui ZouDepartment of Pediatrics, The First Hospital of China Medical University, Shenyang, China.
Mingyue ShiDepartment of Pediatrics, The First Hospital of China Medical University, Shenyang, China.
Lei LiDepartment of Orthopaedic Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Hongkun JiangDepartment of Pediatrics, The First Hospital of China Medical University, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease is a major cause of human morbidity and mortality. With the rising prevalence of cardiovascular diseases and their increasing economic impact on individuals and society, a deeper understanding of their pathogenesis is essential. Macrophages play the crucial role in this regulatory network as key cell types in the innate immune system. This review provides an overview of the subpopulations, heterogeneity, and ontogenetic diversity of macrophages. It emphasizes how various cellular metabolic processes influence the biological functions of macrophages. Additionally, it explores the mechanisms through which macrophages function in different cardiovascular diseases (e.g., atherosclerosis, hypertension, or myocardial infarction) and examines their potential therapeutic applications. The review also addresses the current limitations and future directions for research and therapeutic strategies involving cardiac macrophages in cardiovascular diseases.

Indexed as

atherosclerosiscardiovascular diseasecell metabolismhypertensionmacrophagemechanism of actionmyocardial infarction

Identifiers

PMID40895433
PMCPMC12391810

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.