Evidence map›Paper›PMID 40895429›Full record

ReviewFrontiers in physiology2025

Emerging role of the TCA cycle and its metabolites in lung disease.

Xinan Lu, Aijun Zhang, Huaying Wang, Xinjia Xu, Liping Chen, Lingfang Luo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xinan LuDepartment of Respiratory and Critical Care Medicine, Affiliated Cixi Hospital, Wenzhou Medical University, Ningbo, Zhejiang, China.
Aijun ZhangDepartment of Respiratory and Critical Care Medicine, Affiliated Cixi Hospital, Wenzhou Medical University, Ningbo, Zhejiang, China.
Huaying WangDepartment of Respiratory and Critical Care Medicine, Affiliated People's Hospital, Ningbo University, Ningbo, Zhejiang, China.
Xinjia XuDepartment of Respiratory and Critical Care Medicine, Affiliated Cixi Hospital, Wenzhou Medical University, Ningbo, Zhejiang, China.
Liping ChenDepartment of Respiratory and Critical Care Medicine, Affiliated People's Hospital, Ningbo University, Ningbo, Zhejiang, China.
Lingfang LuoDepartment of Respiratory and Critical Care Medicine, Affiliated Cixi Hospital, Wenzhou Medical University, Ningbo, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The TCA cycle is a central pathway for oxidative phosphorylation in eukaryotic mitochondria, plays a role in energy production and biosynthesis, and can alter cellular function in a variety of ways. As our understanding of the TCA cycle has improved, there is increasing evidence that it is inextricably linked to lung disease. This article summarizes the relationship between the TCA cycle and different types of lung disease and focuses on the specific mechanisms by which the TCA cycle and its intermediate metabolites influence lung disease progression.

Indexed as

asthmachronic obstructive pulmonary disease (COPD)lung cancerlung infectionpulmonary hypertension (PH)TCA cycle

Identifiers

PMID40895429
PMCPMC12394498

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.