Evidence map›Paper›PMID 40895385›Full record

ArticleGlobal health & medicine2025

Surgery for postoperative intrahepatic recurrence after curative resection for hepatocellular carcinoma: Repeat hepatectomy versus salvage liver transplantation.

Takashi Kokudo, Nermin Halkic, Norihiro Kokudo

Abstract readEditorial
In one paragraph

Article in Global health & medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Takashi KokudoNational Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.
Nermin HalkicClinique Cecil, Lausanne, Switzerland.
Norihiro KokudoNational Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver resection (LR) remains a cornerstone curative option for patients with hepatocellular carcinoma (HCC), and yet the high rate of postoperative intrahepatic recurrence poses a significant clinical challenge. Despite numerous attempts, no adjuvant therapy has shown definitive efficacy in preventing recurrence. In this context, salvage liver transplantation (SLT) and repeat hepatectomy (RH) have emerged as key curative strategies for recurrent disease. While SLT is associated with the most favorable survival outcomes, limited donor availability, particularly in Eastern countries, often necessitates the use of RH, which can also offer promising results. These evolving treatment strategies underscore the urgent need for improved risk stratification, optimized surgical decision-making, and innovative approaches to managing recurrent HCC.

Indexed as

hepatocellular carcinomarepeat hepatectomysalvage liver transplantation

Identifiers

PMID40895385
PMCPMC12391185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.