Evidence map›Paper›PMID 40895319›Full record

ArticlePhenomics (Cham, Switzerland)2025

Cell Function Experiments and Bioinformatics Analysis Jointly Revealed the Antineoplastic Effect of Lumican on Hepatocellular Carcinoma.

Xiaoyu Zhou, Zixuan Xing, Ruijun Dong, Xi Zhang, Xuefeng Liang, Zhengyang Lu, Ganghua Yang

Abstract read
In one paragraph

Article in Phenomics (Cham, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoyu Zhou *Department of Geriatric Surgery, First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi Province 710061 China.ORCID 0000-0002-7625-861X
Zixuan Xing *Department of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province 710004 China.ORCID 0000-0001-7935-2575
Ruijun DongHealth Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi Province 710061 China.ORCID 0000-0001-8246-7680
Xi ZhangHealth Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi Province 710061 China.ORCID 0000-0001-9163-7493
Xuefeng LiangMedical School of Yan'an University, Yan'an, Shaanxi Province 716000 China.ORCID 0009-0006-3203-686X
Zhengyang LuDepartment of Geriatric Surgery, First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi Province 710061 China.ORCID 0000-0002-5107-104X
Ganghua YangDepartment of Geriatric Surgery, First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi Province 710061 China.ORCID 0000-0001-9016-2983

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and immune checkpoint inhibitor (ICI)-based therapies are now an integral part of systemic treatment. In this study, we identify potential biomarker for HCC and further investigate its functional significance using both bioinformatic and experimental methods. Differential analysis and weighted gene co-expression network analysis (WGCNA) were conducted, identifying Supplementary Information: The online version contains supplementary material available at 10.1007/s43657-024-00182-w.

Indexed as

BioinformaticsHepatocellular CarcinomaLumicanTumor Mutation Burden

Identifiers

PMID40895319
PMCPMC12391580

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.