ArticleBrain communications2025
Unilateral focused ultrasound thalamotomy for tremor-dominant Parkinson's disease: blinded evaluation and imaging correlation.
Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Functional network reorganization after magnetic resonance-guided focused ultrasound thalamotomy in tremor-dominant Parkinson's disease patients.NeuroImage. Clinical · 2026Article
- Surgical Treatment of Tremor Syndromes: A Guide to the Clinician.Movement disorders clinical practice · 2026Review
- Long-term outcomes after caudal zona incerta-forel field ablation: three-year clinical follow-up in advanced Parkinson's disease.Frontiers in aging neuroscience · 2026Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There have been promising outcomes from the use of unilateral High-intensity focused ultrasound (HiFUS) thalamotomy in tremor-dominant Parkinson's disease. However, the reliability of this treatment has been questioned due to the high rate of tremor relapse. Authors have hypothesized that treatment failure is due to insufficient HiFUS lesion size, though detailed volumetric lesion analyses are lacking. To report the blinded tremor outcomes of unilateral HiFUS thalamotomy in tremor-dominant Parkinson's disease and correlate these outcomes with lesion characteristics, including the dentatorubrothalamic tract ablation overlap, which may provide valuable insights into the mechanisms behind tremor relapse and ultimately refine the optimal HiFUS target for tremor in Parkinson's disease. Retrospective review of consecutively treated tremor-dominant Parkinson's disease patients followed under a uniform protocol. Blinded tremor analysis was completed on pre- and post-operative videos. Patients were classified into two groups: 'responder' (≥50% improvement in Hand Tremor Score) or 'suboptimal responder' (<50% improvement in Hand Tremor Score) at the last follow-up. 17 patients with tremor-dominant Parkinson's disease underwent a unilateral HiFUS thalamotomy at our centre. Pre- and post-operative videos were available in 15 patients for analysis. Baseline median Hand Tremor Score was 11.0 (9.5-14.5), improving to 6.0 (1-13.5) over a median 24-month (3-36) follow-up period (
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