ArticleChem2025
A programmable modular robot for the synthesis of molecular machines.
Article in Chem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Tetragraphene-Based Nanotubes Under Temperature Effects: Atomistic Insights into Nanostructural Degradation via Reactive Molecular Dynamics.Nanomaterials (Basel, Switzerland) · 2026Article
- Illuminating the Interface: In Situ Optical Insights Into Two-Electron ORR Pathways for HAdvanced materials (Deerfield Beach, Fla.) · 2026Review
- Data Management and Analysis of Metal-Organic Framework Synthesis Using Data Models.Journal of chemical information and modeling · 2026Article
- Article
- Utilizing Similarity Measures to Map Chemical Reactivity.Angewandte Chemie (International ed. in English) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The assembly of molecular nanomachines using atomically precise manipulations promises to enable nanotechnology with unprecedented architectural features and exquisite functional properties. However, this future is critically limited by the ability to autonomously manufacture nanomachines, with current efforts being heavily labor intensive. A system is needed to program and assemble matter under digital control, unifying molecular nanotechnology and macroscale chemical processes. Herein, we present a universal chemical robotic synthesis platform (Chemputer) that produces functional molecular machines. By integrating autonomous feedback through on-line NMR and liquid chromatography, a divergent four-step synthesis and purification of molecular rotaxane architectures are achieved. The synthetic sequence averaged 800 base steps over 60 h, affording products on an analytical scale for feasibility studies. While standardizing rotaxane synthesis enhances reliability and reproducibility, our workflow addresses two bottlenecks in autonomous synthesis: yield determination (via on-line
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.