ArticleClinical parkinsonism & related disorders2025
Validation of the English version of the Parkinson Anxiety Scale in two Canadian Parkinson's disease samples.
Article in Clinical parkinsonism & related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Probiotic supplementation for anxiety symptoms in people with Parkinson's disease: a randomized, double-blind, placebo-controlled trial.NPJ Parkinson's disease · 2026Article
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10 authors.
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Abstract
Introduction: The 12-item Parkinson Anxiety Scale (PAS) assesses the severity of anxiety symptoms in people with Parkinson's disease (PwP). However, psychometric evidence supporting the English self-rated PAS remains largely limited to validation studies by the developers. This study aimed to reinforce validation of this scale through a comprehensive psychometric evaluation in PwP in Canada. Methods: Data were drawn from two Canadian samples of 130 and 53 PwP, respectively, at a tertiary center. Acceptability, reliability, validity, and factor structure were assessed. The Mini International Neuropsychiatric Interview was administered to confirm anxiety diagnoses. Optimal cut-off scores suggesting the presence of an anxiety disorder were determined using receiver operating characteristic (ROC) curve analysis. Results: The PAS and its three subscales demonstrated good acceptability and internal consistency reliability (Cronbach's α > 0.70). Good convergent validity with the State-Trait Anxiety Inventory and divergent validity with scales assessing other non-motor symptoms were obtained. Confirmatory factor analysis supported the three-factor structure (comparative fit index = 0.987; Tucker-Lewis index = 0.983; root mean square error of approximation = 0.083; standardized root mean square residual = 0.087). Optimal cut-off scores were 12.5 for the total PAS (area under the ROC curve = 0.81, sensitivity = 0.89, specificity = 0.58), 8.5 for the persistent anxiety subscale, and 2.5 for the episodic anxiety and avoidance behavior subscales. Approximately 22 % of participants in the larger sample had a diagnosed anxiety disorder. Conclusion: The English self-rated PAS is a valid and reliable instrument for screening and assessing severity and dimensions of anxiety in PwP.
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