ArticleFood science & nutrition2025
Identification of Metabolite Biomarkers Associated With Dietary Patterns in Individuals With Mild Cognitive Impairment and Dementia From Yucatan.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Identification of Metabolite Biomarkers Associated With Dietary Patterns in Individuals With Mild Cognitive Impairment and Dementia From Yucatan.Food science & nutrition · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many countries have experienced a dietary transition marked by an increased consumption of ultra-processed foods, which is associated with poorer cognitive function. Our research group has previously identified the dietary patterns of patients with MCI and dementia, showing a significant nutritional deficiency, as the intake of vegetables, fruits, and proteins was inadequate. The identification of early biomarkers, such as metabolites associated with dietary patterns, in individuals with MCI and dementia in Mexico has not yet been explored. These metabolites could provide insights into the nutritional response or changes in individuals with these conditions and may serve as targets for early intervention. To address this gap, the aim of this study was to investigate the metabolite profiles of older adults, comparing those with neurocognitive impairments (cases) to those without (controls), based on their dietary patterns. A cross-sectional study was carried out among 39 patients as controls and 34 individuals as cases (MCI and dementia). Concentrations of serum acylcarnitines, free carnitine, and amino acids were measured using the approach of targeted metabolomics by electrospray tandem mass spectrometry and evaluated through partial least-squares discriminant analysis (PLS-DA). Six metabolites "Ornithine, C18OH, Alanine, C8, C10, and C5" were identified for individuals with MCI and dementia. Levels of ornithine were correlated to the consumption of pastries and cookies (
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