ArticleFood science & nutrition2025
Investigating the Impact of Aspartame on Ulcerative Colitis Through Network Toxicology and Molecular Docking.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Integrative bioinformatics and machine learning approaches identify inflammation-related genes and drug candidates for future preclinical validation in ischemic stroke.BMC neurology · 2025Article
- Investigating the Impact of Aspartame on Ulcerative Colitis Through Network Toxicology and Molecular Docking.Food science & nutrition · 2025Article
- Investigating the impact of aspartame on Alzheimer's disease through network toxicology and molecular docking.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study is to elucidate the impact of aspartame on ulcerative colitis (UC). The research methodology involved extracting aspartame-associated targets from the ChEMBL and STITCH databases, while potential UC-related targets were obtained from the OMIM and GeneCards databases. The STRING platform and Cytoscape software were utilized to identify key targets through which aspartame may exert its influence on UC. Comprehensive analyses of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were conducted using the DAVID database. Furthermore, molecular docking simulations were employed to validate the binding interactions between aspartame and these key targets. A total of 297 targets associated with aspartame and 5968 targets related to UC were identified. Protein-protein interaction (PPI) analysis indicated that BCL2, ESR1, HSP90AA1, SRC, TNF, and CASP3 may serve as central targets through which aspartame affects UC. KEGG pathway analysis highlighted the involvement of pathways such as the C-type lectin receptor, sphingolipid, and VEGF signaling pathways. In molecular docking studies, a binding energy of less than -5.0 kcal mol
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.