Evidence map›Paper›PMID 40895065›Full record

ArticlePeerJ2025

A retrospective analysis of neoadjuvant chemotherapy in pneumonectomy for locally advanced central non-small cell lung cancer.

Yuchen Wang, Zhihang Dang, Pu Jiang, Zhifeng Li, Jin Yang, Kun Gao, Xiaona Chen, Jifang Yao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuchen Wang *Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.ORCID 0009-0009-1031-4541
Zhihang Dang *Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Pu JiangDepartment of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Zhifeng LiDepartment of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Jin YangDepartment of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Kun GaoDepartment of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Xiaona ChenDepartment of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Jifang YaoDepartment of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: The treatment of patients with locally advanced central non-small cell lung cancer (NSCLC) remains controversial. This study aimed to evaluate the effects of neoadjuvant chemotherapy in patients undergoing pneumonectomy. Methods: A retrospective analysis was conducted on patients who underwent pneumonectomy with or without neoadjuvant chemotherapy for locally advanced central NSCLC between 2014 and 2019. Categorical variables were compared using the Chi-square or Fisher's exact test. Survival analysis was performed using the Kaplan-Meier method, with comparisons made Results: Based on inclusion and exclusion criteria, 104 patients were selected from a total of 6,930, including 69 who received neoadjuvant chemotherapy and 35 who did not. Univariate analysis showed that the neoadjuvant chemotherapy group had significantly improved 5-year overall survival (OS: 29.1% Conclusions: Neoadjuvant chemotherapy significantly improves prognosis in patients with locally advanced central NSCLC undergoing pneumonectomy. Multivariate analysis confirms its positive impact on survival. Patients who experience downstaging after neoadjuvant chemotherapy show notably better outcomes. For patients with stage cN2 disease, neoadjuvant chemotherapy is associated with improved survival.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsNeoadjuvant TherapyPneumonectomyAdultAgedChemotherapy, AdjuvantDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm StagingRetrospective StudiesLocally advanced central lung cancerNeoadjuvant chemotherapyNon-small cell lung cancerPneumonectomy

Identifiers

PMID40895065
PMCPMC12398283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.