Evidence map›Paper›PMID 40895036›Full record

ArticleBrain & spine2025

The value of white blood cell count and platelet count in predicting delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.

Eva Postma, Homeyra Labib, Jordi van Lange, Bert Coert, René Post, René van den Berg, Charles Majoie, W Peter Vandertop, Dagmar Verbaan

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Article in Brain & spine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Eva PostmaAmsterdam UMC, Location AMC, University of Amsterdam, Department of Neurosurgery, Meibergdreef 9, Amsterdam, the Netherlands.
Homeyra LabibAmsterdam UMC, Location AMC, University of Amsterdam, Department of Neurosurgery, Meibergdreef 9, Amsterdam, the Netherlands.
Jordi van LangeAmsterdam UMC, Location AMC, University of Amsterdam, Department of Neurosurgery, Meibergdreef 9, Amsterdam, the Netherlands.
Bert CoertAmsterdam UMC, Location AMC, University of Amsterdam, Department of Neurosurgery, Meibergdreef 9, Amsterdam, the Netherlands.
René PostAmsterdam UMC, Location AMC, University of Amsterdam, Department of Neurosurgery, Meibergdreef 9, Amsterdam, the Netherlands.
René van den BergAmsterdam UMC, Location AMC, University of Amsterdam, Department of Radiology and Nuclear Medicine, Meibergdreef 9, Amsterdam, the Netherlands.
Charles MajoieAmsterdam UMC, Location AMC, University of Amsterdam, Department of Radiology and Nuclear Medicine, Meibergdreef 9, Amsterdam, the Netherlands.
W Peter VandertopAmsterdam UMC, Location AMC, University of Amsterdam, Department of Neurosurgery, Meibergdreef 9, Amsterdam, the Netherlands.
Dagmar VerbaanAmsterdam UMC, Location AMC, University of Amsterdam, Department of Neurosurgery, Meibergdreef 9, Amsterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) contributes significantly to mortality and morbidity. Neuroinflammation and platelet activation are implicated in its pathophysiology. Research question: This study evaluates the association of admission white blood cell count (WBC) and platelet count (PC), and their combination, with DCI and explores their integration into predictive models. Materials and methods: This single-center cohort study utilized data from a prospective SAH registry (December 2011-December 2019). Patients with confirmed aSAH and recorded WBC and PC within 72 h post-ictus were included. Univariate and multivariate regression models with established predictors, consisting of the modified Fisher scale (mFS) and World Federation of Neurological Surgeons grade (WFNS), were performed. Predictive values were assessed using AUCs (95 % CI) and C-statistics. Results: Of 954 reviewed patients, 660 met inclusion criteria, with 178 (27.0 %) developing DCI. Patients who developed DCI had significantly higher admission WBC levels (mean (SD) 14.3 (5.1) × 10 Discussion and conclusion: Admission WBC and PC offer modest predictive value for DCI, either alone or combined with neurological status and hemorrhage burden. However, WBC demonstrated highest predictive value of all investigated variables and modestly improves prediction models. Future research should evaluate WBC's utility in models with enhanced predictive performance.

Indexed as

Aneurysmal subarachnoid hemorrhageDelayed cerebral ischemiaPlatelet countPredictionWhite blood cell count

Identifiers

PMID40895036
PMCPMC12391828

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.