ArticleiScience2025
The elucidation of the dual role of Beclin-1 in ischemic stroke through systems biology modeling.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A Ternary Flavonoid Formulation Mitigates Fractional Radiation-Induced Brain Injury via Transcriptomic Reprogramming and Synaptic Protection.International journal of molecular sciences · 2026Article
- Lysosome Evanescence Mediates Autophagic Flux Impairment in Glucose Imbalanced Environments.The Kaohsiung journal of medical sciences · 2026Article
- Unveiling the neuroprotective power: the role of autophagy in remote ischemic conditioning.Metabolic brain disease · 2025Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beclin-1 plays a pivotal role in the interplay between autophagy and apoptosis in ischemic stroke, influencing both cell survival and death. We developed a mathematical model incorporating the dual role of Beclin-1 to simulate Beclin-1-induced autophagy and apoptosis under varying ischemic stress conditions. The model predicts a critical threshold of Beclin-1 expression, beyond which apoptosis is triggered, with this threshold decreasing as stress severity increases. To validate the model predictions, we conducted
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Registered trials
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