Evidence map›Paper›PMID 40894896›Full record

ArticleiScience2025

Elovl1 inhibition reduced very long chain fatty acids in a mouse model of adrenoleukodystrophy.

Jeremy Y Huang, Brian Freed, Martin Hanus, Kelly Keefe, Ming Sum Ruby Chiang, Alexander Brezzani, Yongyi Luo, Yihang Li, Becky Lam, Stephanie Holley and 31 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Jeremy Y HuangResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Brian FreedResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Martin HanusResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Kelly KeefeResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Ming Sum Ruby ChiangResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Alexander BrezzaniResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Yongyi LuoResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Yihang LiResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Becky LamResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Stephanie HolleyResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Joseph GansResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Zuzana DostalovaResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Buyun TangResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Clifford PhaneufResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Erin TeepleResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Laura ParisiResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Lilu GuoResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Zhonglin ZhaoResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Sofia N KintonResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Jacquelyn DwyerResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Sandrine TeixeiraResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Hong MaResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Gary AsmussenResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Rajashree McLarenResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Donghui WangResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Ann BakerResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Craig S SiegelResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
David FinkResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Kristen RandallResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Alexei BelenkyResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Suchitra VenugopalResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Giorgio GagliaResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Jennifer JohnsonResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Dinesh S BangariResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Bailin ZhangResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Alexander MichelResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Jonathan D ProtoResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Alla KlossResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
S Pablo SardiResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Tatiana GladyshevaResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.
Can KayatekinResearch and Development, Sanofi, 350 Water Street, Cambridge, MA 02141, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adrenoleukodystrophy (ALD) is a rare neurometabolic disease caused by mutations in the

Indexed as

Molecular interactionMolecular mechanism of gene regulationMolecular neuroscienceTranscriptomics

Identifiers

PMID40894896
PMCPMC12392333

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.