Evidence map›Paper›PMID 40894873›Full record

ArticleiScience2025

5-HT6R-ATR-primary cilia network supports morphine-related memory extinction in the medial prefrontal cortex.

Junlin Liu, Xixi Yang, Feifei Gao, Jingsi Yang, Zhuojin Yang, Qi Liao, Mengqing Shen, Dongyu Yu, Yuxiang Zhang, Chunxia Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Junlin LiuCollege of Forensic Medicine, Key Laboratory of National Health Commission for Forensic Medicine, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Xixi YangCollege of Forensic Medicine, Key Laboratory of National Health Commission for Forensic Medicine, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Feifei GaoCollege of Forensic Medicine, Key Laboratory of National Health Commission for Forensic Medicine, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Jingsi YangCollege of Forensic Medicine, Key Laboratory of National Health Commission for Forensic Medicine, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Zhuojin YangCollege of Forensic Medicine, Key Laboratory of National Health Commission for Forensic Medicine, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Qi LiaoKey Laboratory of Drugs Analysis & Intelligent Monitoring, National Anti-Drug Laboratory Shaanxi Regional Center, Xixian New Area 712000, Shaanxi, China.
Mengqing ShenCollege of Forensic Medicine, Key Laboratory of National Health Commission for Forensic Medicine, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Dongyu YuCollege of Forensic Medicine, Key Laboratory of National Health Commission for Forensic Medicine, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Yuxiang ZhangCollege of Forensic Medicine, Key Laboratory of National Health Commission for Forensic Medicine, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Chunxia YanCollege of Forensic Medicine, Key Laboratory of National Health Commission for Forensic Medicine, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug addiction involves pathological learning and memory with serious personal and societal effects. Primary cilia on the cell surface are crucial for signal transduction. The 5-HT6R, highly localized in primary cilia, is linked to cognitive and emotional disorders, but its role in morphine-related reward memory is unclear. Using a morphine-induced conditioned place preference (CPP) model, we found that 5-HT6R in the medial prefrontal cortex was selectively downregulated during early extinction, but unchanged in CPP establishment or reinstatement. Knockdown of 5-HT6R accelerated extinction, while overexpression delayed it. These effects required intact cilia, as cilia shortening or IFT88 knockdown promoted extinction. Mechanistically, ATR was identified as a 5-HT6R-binding protein that regulates cilia structure. ATR knockdown mimicked and enhanced the extinction-promoting effect of 5-HT6R suppression, which was blocked by cilia disruption. These findings reveal a 5-HT6R-ATR-Primary cilia network that controls the extinction of morphine-induced reward memory, suggesting therapeutic targets for opioid addiction.

Indexed as

Behavioral neuroscienceCell biologyMolecular biologyNeuroscience

Identifiers

PMID40894873
PMCPMC12395986

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.