Evidence map›Paper›PMID 40894845›Full record

ArticleCJC open2025

Association of Left Atrial Dysfunction with Pulmonary Hemodynamics and Cardiovascular Outcomes in Patients with Systemic Sclerosis.

Kazutoshi Hirose, Koki Nakanishi, Masao Daimon, Hikari Seki, Yuriko Yoshida, Megumi Hirokawa, Tomoko Nakao, Koichi Kimura, Shun Minatsuki, Masaru Hatano and 5 more

Abstract read
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In one paragraph

Article in CJC open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kazutoshi HiroseDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
Koki NakanishiDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
Masao DaimonDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
Hikari SekiDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
Yuriko YoshidaDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
Megumi HirokawaDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
Tomoko NakaoDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
Koichi KimuraDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
Shun MinatsukiDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
Masaru HatanoDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
Hiroyuki MoritaDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
Marco R Di TullioDepartment of Medicine, Columbia University, New York, New York, USA.
Shunichi HommaDepartment of Medicine, Columbia University, New York, New York, USA.
Makoto KuranoDepartment of Clinical Laboratory, The University of Tokyo, Tokyo, Japan.
Norihiko TakedaDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Left atrial (LA) reservoir strain (LARS) is emerging as an early marker of cardiac remodelling, providing significant prognostic information. The present study investigated the prevalence of LA dysfunction and its association with pulmonary hemodynamics and cardiovascular (CV) outcomes in systemic sclerosis (SSc) patients. Methods: We included 52 patients who had SSc without structural cardiac disease. All patients underwent 2-dimensional transthoracic echocardiography and right heart catheterization. LARS was assessed by using speckle-tracking analysis. The study outcome was a composite of heart failure or pulmonary hypertension (PH)-related hospitalization, lung transplantation, and CV death. Results: Abnormal LARS (< 24%) was present in 18 patients (34.6%). Despite the similar prevalence of PH between groups with abnormal vs normal LARS ( Conclusions: LA dysfunction was related to unfavourable pulmonary artery remodelling and adverse outcomes in SSc patients without structural cardiac disease.

Identifiers

PMID40894845
PMCPMC12399056

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.