Evidence map›Paper›PMID 40894800›Full record

ArticlebioRxiv : the preprint server for biology2025

DFFB suppresses interferon to enable cancer persister cell regrowth.

August F Williams, David A G Gervasio, Claire E Turkal, Anna E Stuhlfire, Michael X Wang, Brandon E Mauch, Rhea Plawat, Ariel H Nguyen, Michelle H Paw, Mehrshad Hairani and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

August F WilliamsDepartment of Dermatology, School of Medicine, University of California San Diego.ORCID 0000-0003-1994-2033
David A G GervasioDepartment of Dermatology, School of Medicine, University of California San Diego.ORCID 0000-0001-8604-8897
Claire E TurkalDepartment of Dermatology, School of Medicine, University of California San Diego.
Anna E StuhlfireDepartment of Dermatology, School of Medicine, University of California San Diego.ORCID 0000-0002-9303-3295
Michael X WangDepartment of Dermatology, School of Medicine, University of California San Diego.
Brandon E MauchDepartment of Dermatology, School of Medicine, University of California San Diego.
Rhea PlawatDepartment of Dermatology, School of Medicine, University of California San Diego.ORCID 0009-0001-4674-0333
Ariel H NguyenDepartment of Dermatology, School of Medicine, University of California San Diego.ORCID 0000-0002-2525-8011
Michelle H PawDepartment of Dermatology, School of Medicine, University of California San Diego.
Mehrshad HairaniDepartment of Dermatology, School of Medicine, University of California San Diego.
Cooper P LathropDepartment of Dermatology, School of Medicine, University of California San Diego.ORCID 0009-0006-7070-3547
Sophie H HarrisDepartment of Dermatology, School of Medicine, University of California San Diego.
Jennifer L PageStem Cell Core, Salk Institute for Biological Studies, La Jolla, CA.ORCID 0000-0002-5822-0298
Matthew J HangauerDepartment of Dermatology, School of Medicine, University of California San Diego.ORCID 0000-0002-5008-6696

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUSAN JANET LITTLE · 1994 to 2026
$78.4M
Contemporary Approaches to Cancer Cell Signaling and CommunicationT32CA009523 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DONOGHUE, DANIEL J, YANG, JING · 1985 to 2025
$12.1M
Predoctoral and Postdoctoral Training in Cancer Cell BiologyT32CA067754 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEAN Y.J. WANG · 1995 to 2026
$6.5M
Functional Networks for Persister Cell SensitivitiesR01CA212767 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCMANUS, MICHAEL T · 2017 to 2021
$2.6M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
NCI NIH HHS P30 CA023100NCI NIH HHS R01 CA212767NCI NIH HHS T32 CA009523NCI NIH HHS T32 CA067754NIAID NIH HHS P30 AI036214NIH HHS S10 OD026929
6 · The paper itself

Abstract

Oncogene targeted cancer therapies can provide deep responses but frequently suffer from acquired resistance.

Identifiers

PMID40894800
PMCPMC12393451

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.