ArticlebioRxiv : the preprint server for biology2025
Closed-Loop Connectivity Best Supports Angular Tuning and Sleep Dynamics in a Biophysical Thalamocortical Circuit Model.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Despite recent advancements in mapping thalamic and cortical projections, the specific organization of intrathalamic and corticothalamic connectivity remains elusive. Current experimental approaches cannot definitively determine whether these connections are arranged in reciprocal (closed-) or non-reciprocal (open-loop) circuits. We developed a biophysically detailed multi-compartmental model of the mouse whisker pathway, built on anatomical and physiological data. We showed that closed-loop intrathalamic projections between the thalamocortical (TC) relay neurons in the ventral posteromedial nucleus and the inhibitory neurons in the thalamic reticular nucleus (TRN) best reproduce thalamic spiking and local field potential responses across awake and sleep states. Increasing the percentage of closed-loop projections regulates the angular tuning in the awake state, while also supporting spindle oscillations during sleep. We also showed that direct activation of closed-loop corticothalamic feedback (CT→TC and CT→TRN) simulating TC inputs sharpens the angular tuning in the thalamus. These results contribute to resolving a long-standing question regarding the organization of intrathalamic projections, offering mechanistic insights into how thalamo-cortical circuits balance precise sensory tuning with robust oscillatory rhythms across behavioral states.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.