Evidence map›Paper›PMID 40894772›Full record

ArticlebioRxiv : the preprint server for biology2025

Free fatty acid receptor 4 agonists stimulate insulin secretion via different mechanisms in mouse versus human islets.

Laura Reininger, Muhammad Rehman, Amélia Bouabcha, Sarah Ferragne, Caroline Tremblay, Mélanie Ethier, Michelle E Kimple, Julien Ghislain, Mark O Huising, Vincent Poitout

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Laura ReiningerUniversity of Montreal Hospital Research Center (CRCHUM), Montreal, QC, Canada.
Muhammad RehmanDepartment of Neurobiology, Physiology & Behavior, College of Biological Sciences, University of California Davis, Davis, CA, USA.
Amélia BouabchaUniversity of Montreal Hospital Research Center (CRCHUM), Montreal, QC, Canada.
Sarah FerragneUniversity of Montreal Hospital Research Center (CRCHUM), Montreal, QC, Canada.
Caroline TremblayUniversity of Montreal Hospital Research Center (CRCHUM), Montreal, QC, Canada.
Mélanie EthierUniversity of Montreal Hospital Research Center (CRCHUM), Montreal, QC, Canada.
Michelle E KimpleUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Julien GhislainUniversity of Montreal Hospital Research Center (CRCHUM), Montreal, QC, Canada.
Mark O HuisingDepartment of Neurobiology, Physiology & Behavior, College of Biological Sciences, University of California Davis, Davis, CA, USA.
Vincent PoitoutUniversity of Montreal Hospital Research Center (CRCHUM), Montreal, QC, Canada.ORCID 0000-0002-6555-5053

Funding

Integrated Islet Distribution Program (U24) - 2021U24DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Carmella Evans-Molina, Joyce Carol Niland · 2021 to 2026
$17.8M
FFA4 regulation of pancreatic islet functionR01DK132597 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HUISING, MARK O., POITOUT, VINCENT · 2022 to 2025
$1.9M
The role of G protein-dependent and -independent EP3 signaling in beta-cell compensation and diabetesR01DK137505 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Michelle E Kimple · 2024 to 2026
$1.9M
BLRD VA I01 BX003700BLRD VA I01 BX005804BLRD VA IK6 BX006804NIDDK NIH HHS R01 DK132597NIDDK NIH HHS R01 DK137505NIDDK NIH HHS U24 DK098085
6 · The paper itself

Abstract

The free fatty acid receptor FFAR4 is expressed in pancreatic islets, and its activation potentiates insulin and inhibits somatostatin (SST) secretion. We investigated the mechanisms of action of FFAR4 on hormone secretion in mouse and human islets. The effects of the FFAR4 agonist Compound A (Cpd A) on insulin and SST secretion were investigated in islets from mice following ablation of δ cells, deletion of SST and deletion of the G protein Gα

Indexed as

FFAR4GPR120Gαzinsulinisletssomatostatin

Identifiers

PMID40894772
PMCPMC12393430

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.