Evidence map›Paper›PMID 40894746›Full record

ArticlebioRxiv : the preprint server for biology2025

Activity-driven proprioceptive synaptic refinement in the developing spinal cord by complement signaling mechanisms.

Chetan Nagaraja, Serena Ortiz, Akash R Murali, Theanne N Griffith

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chetan NagarajaDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA.ORCID 0000-0001-9768-9462
Serena OrtizDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-4872-1360
Akash R MuraliDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-7696-0505
Theanne N GriffithDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-0090-6286

Funding

Initiative for Maximizing Student Development at the University of California, Davis.T32GM135741 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ALDRIN V. GOMES, Manuel F Navedo · 2020 to 2026
$3.2M
The UC Davis enhanced Molecular, Cellular, and Developmental Biology Training ProgramT32GM153586 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Frederic Louis Chedin, ELVA D DIAZ · 2024 to 2026
$2.3M
The electrical basis of proprioceptive signalingR01NS135005 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Theanne Nicole Griffith · 2024 to 2026
$1.4M
NIGMS NIH HHS T32 GM135741NIGMS NIH HHS T32 GM153586NINDS NIH HHS R01 NS135005
6 · The paper itself

Abstract

Proprioceptive group Ia afferents detect muscle stretch to guide effortless and purposeful movement and make monosynaptic connections with spinal α-motor neurons to mediate reflexes, such as the stretch reflex. It is thought that proprioceptive Ia afferents target motor neurons of the same spinal segment; yet, how this specificity, if any, is established during early development is unknown. Using

Identifiers

PMID40894746
PMCPMC12393565

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.