Evidence map›Paper›PMID 40894710›Full record

ArticlebioRxiv : the preprint server for biology2025

SALL4 is required for

Minwook Kim, Yoojeong Park, Rachel Covitz, Joseph Kwon, Jia-Jun Liu, Silvia Liu, Sungjin Ko

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Minwook KimDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA USA.ORCID 0000-0002-0093-4562
Yoojeong ParkDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA USA.
Rachel CovitzDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA USA.
Joseph KwonDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA USA.
Jia-Jun LiuDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA USA.
Silvia LiuDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA USA.
Sungjin KoDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA USA.ORCID 0000-0002-6079-5939

Funding

Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gavin E Arteel · 2019 to 2026
$10.9M
Identifying therapeutic options for intrahepatic cholangiocarcinomaR01CA258449 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KO, SUNGJIN · 2021 to 2025
$1.6M
Deciphering the Molecular Mechanisms Underlying Cholangiocarcinoma DevelopmentR01CA300059 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sungjin Ko · 2025 to 2026
$1.0M
High-Throughput Computing for Genomics and Bioinformatics ResearchS10OD028483 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, ADRIAN V · 2021 to 2021
$574k
NCI NIH HHS R01 CA258449NCI NIH HHS R01 CA300059NIDDK NIH HHS P30 DK120531NIH HHS S10 OD028483
6 · The paper itself

Abstract

Hepatocytes (HCs), which share a developmental origin with cholangiocytes (CCs), have the capacity to undergo reparative reprogramming into CCs in response to liver injury and, under specific conditions, can also transform malignantly into cholangiocarcinoma (CCA). However, the molecular mechanisms governing HC plasticity in liver diseases remain poorly understood. In this study, we investigated the role of

Indexed as

bile ductKRASliver cancermixed hepatocellular carcinoma/cholangiocarcinomaNRASplasticitytrans-differentiation

Identifiers

PMID40894710
PMCPMC12393310

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.