ArticlebioRxiv : the preprint server for biology2025
Mechanistic Insights into Sex Differences in Atrial Electrophysiology and Arrhythmia Vulnerability through Sex-specific Computational Models.
Nathaniel T Herrera, Haibo Ni, Charlotte E R Smith, Yixuan Wu, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors.
Nathaniel T HerreraDepartment of Pharmacology, University of California Davis, Davis, California, United States.
Haibo NiDepartment of Pharmacology, University of California Davis, Davis, California, United States.
Charlotte E R SmithDepartment of Pharmacology, University of California Davis, Davis, California, United States.ORCID 0000-0002-1165-1752 Yixuan WuDepartment of Pharmacology, University of California Davis, Davis, California, United States.
Dobromir DobrevInstitute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany.
Stefano MorottiDepartment of Pharmacology, University of California Davis, Davis, California, United States.ORCID 0000-0001-8679-665X Eleonora GrandiDepartment of Pharmacology, University of California Davis, Davis, California, United States.
Funding
Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI MARK MERCOLA · 2019 to 2026
$21.1MDevelopment of the Predictive NeuroCardiovascular SimulatorOT2OD026580 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, GRANDI, ELEONORA · 2018 to 2021
$5.7MThe Role of Inflammasome in the Pathogenesis of Atrial FibrillationR01HL136389 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Na Li · 2017 to 2026
$5.6MSex-specific arrhythmogenic mechanisms of atrial fibrillationR01HL131517 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eleonora Grandi · 2016 to 2026
$5.0MFunctional Microdomains in the Heart's Pacemaker: A New Dimension of Cardiac RemodelingR01HL141214 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Alexey V Glukhov · 2018 to 2026
$3.8MMultiomics and Functional Characterization Establish Druggable Targets for PVC-Driven Idiopathic VFR01HL170521 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Eleonora Grandi · 2023 to 2026
$3.1MResolution of inflammation and atrial fibrillationR01HL165704 · NHLBI · UNIVERSITY OF MINNESOTA · PI SAMUEL C DUDLEY · 2023 to 2026
$2.9MCardiac fibroblast inflammasome and atrial myopathyR01HL163277 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LI, NA · 2022 to 2025
$2.8MRole of Nucleoside-Diphosphate Kinase Signaling in Atrial FibrillationR01HL160992 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens · 2023 to 2026
$2.1MPhosphodiesterase 1 (PDE1) Regulation of Myocardial Calcium and FunctionR01HL171586 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI Grace Kim Muller · 2024 to 2026
$1.9MPhenotype-specific models, mechanisms, and treatment of HFpEFR01HL171057 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Stefano Morotti · 2024 to 2026
$1.8MFKBP5 AND CARDIAC ARRHYTHMOGENESISR01HL164838 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Na Li · 2024 to 2026
$1.7MNHLBI NIH HHS P01 HL141084NHLBI NIH HHS R00 HL138160NHLBI NIH HHS R01 HL131517NHLBI NIH HHS R01 HL136389NHLBI NIH HHS R01 HL141214NHLBI NIH HHS R01 HL160992NHLBI NIH HHS R01 HL163277NHLBI NIH HHS R01 HL164838NHLBI NIH HHS R01 HL165704NHLBI NIH HHS R01 HL170521NHLBI NIH HHS R01 HL171057NHLBI NIH HHS R01 HL171586NHLBI NIH HHS R01 HL176651NIA NIH HHS R03 AG086695NIH HHS OT2 OD026580
6 · The paper itselfAbstract
Atrial fibrillation (AF), the most common cardiac arrhythmia, is characterized by notable sex differences in clinical presentation, treatment response, and outcomes. Although prevalence is similar between sexes, women often experience more severe symptoms, higher rates of adverse drug effects, and reduced treatment efficacy. To investigate the underlying sex-specific AF mechanisms, we developed and validated male and female human atrial cardiomyocyte models that integrate known sex-based differences in electrophysiology and calcium (Ca
Indexed as
antiarrhythmicsAtrial fibrillationcomputational modelingelectrophysiologypharmacologysex differences
Identifiers
PMID40894654
PMCPMC12393410
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