ArticlebioRxiv : the preprint server for biology2025
Early, adjuvant-responsive epigenetic programs in B cells imprint subsequent plasma cell survival and the duration of humoral immunity.
Tyler J Ripperger, Lucas J D'Souza, James F Read, Wenjie Qi, Darren A Cusanovich, Stacey Schultz-Cherry, Lynn M Corcoran, Anthony Bosco, Deepta Bhattacharya
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Tyler J RippergerDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Lucas J D'SouzaDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
James F ReadDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Wenjie QiDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Darren A CusanovichAsthma and Airway Disease Research Center, The BIO5 Institute, University of Arizona, Tucson, AZ, USA.
Stacey Schultz-CherryDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-2021-727X Lynn M CorcoranThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Anthony BoscoDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Deepta BhattacharyaDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA.ORCID 0000-0001-8377-7699 Funding
VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2MTRANSCRIPTIONAL REGULATION OF ANTIBODY RESPONSES AND IMMUNITYR01AI099108 · NIAID · WASHINGTON UNIVERSITY · PI Deepta Bhattacharya · 2012 to 2026
$6.4MGLUCOSE AND AMINO ACID CATABOLISM IN PLASMA CELL BIOLOGYR01AI129945 · NIAID · UNIVERSITY OF ARIZONA · PI Deepta Bhattacharya · 2018 to 2026
$4.8MBeyond Pseudotime: Enhanced Single-cell Genomics Tools for Understanding the Temporal Dynamics of Development and DiseaseR35GM137896 · NIGMS · UNIVERSITY OF ARIZONA · PI CUSANOVICH, DARREN A · 2020 to 2024
$1.8MSystemic and intercellular gene networks underlying RV-induced airways diseaseR21AI176305 · NIAID · UNIVERSITY OF ARIZONA · PI BOSCO, ANTHONY · 2023 to 2024
$422kNCI NIH HHS P30 CA023074NIAID NIH HHS R01 AI099108NIAID NIH HHS R01 AI129945NIAID NIH HHS R21 AI176305NIGMS NIH HHS R35 GM137896
6 · The paper itselfAbstract
The duration of antibody production varies across different infections and vaccines. To define molecular programs that promote durable humoral immunity, we used mice deficient in ZBTB20, a transcription factor that is highly expressed by plasma cells and required to maintain antibody production
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PMID40894624
PMCPMC12393448
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