Evidence map›Paper›PMID 40894621›Full record

ArticlebioRxiv : the preprint server for biology2025

A PBD-dimer containing antibody drug conjugate targeting CCRL2 for high-risk MDS/AML.

Nour Sabiha Naji, Taha Ahmedna, J David Peske, Xinghan Zeng, Brandy Perkins, Zanshe Thompson, Tushar D Nichakawade, Bum Seok Lee, Evangeline Watson, Theodora Chatzilygeroudi and 14 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Taha Ahmedna
J David Peske
Xinghan Zeng
Brandy Perkins
Zanshe Thompson
Tushar D Nichakawade
Bum Seok Lee
Evangeline Watson
Theodora Chatzilygeroudi
Li Luo
Bogdan Paun
Melanie Klausner
Yuju An
Teodora Supeanu
Ivana Gojo
Gabriel Ghiaur
Amy E DeZern
Mark J Levis
Linda Resar
Richard J Jones
Styliani Karanika
Suman Paul
Theodoros KarantanosORCID 0000-0002-6792-8298

Funding

TCR Targeting Antibodies for the Treatment of T cell CancersK08CA270403 · NCI · JOHNS HOPKINS UNIVERSITY · PI Suman Paul · 2022 to 2026
$1.1M
Bispecific Antibody Maintenance Therapy after Allogeneic Bone Marrow TransplantK08CA276987 · NCI · JOHNS HOPKINS UNIVERSITY · PI Jonathan Allen Webster · 2023 to 2026
$948k
CCRL2 as a Regulator of Growth and Novel Target in Myelodysplastic SyndromeK08HL168777 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Theodoros Karantanos · 2023 to 2026
$687k
Mechanisms of a therapeutic DNA vaccine targeting Mycobacterium tuberculosis persistersK08AI174959 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Styliani Karanika · 2024 to 2026
$603k
NCI NIH HHS K08 CA270403NCI NIH HHS K08 CA276987NHLBI NIH HHS K08 HL168777NIAID NIH HHS K08 AI174959
6 · The paper itself

Abstract

Patients with myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) with high-risk features including Statement of significance: Pyrrolobenzodiazepine(PBD)-conjugated anti-CCRL2 ADC shows anti-leukemic effect in MDS/AML models including

Identifiers

PMID40894621
PMCPMC12393445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.