Evidence map›Paper›PMID 40894617›Full record

ArticlebioRxiv : the preprint server for biology2025

White Matter Tract Vulnerability to Amyloid Pathology on the Alzheimer's Disease Continuum.

Bramsh Qamar Chandio, Talia M Nir, Julio E Villalon-Reina, Sophia I Thomopoulos, Yixue Feng, Robert I Reid, Clifford R Jack, Michael W Weiner, Eleftherios Garyfallidis, Neda Jahanshad and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Bramsh Qamar ChandioImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Talia M NirImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Julio E Villalon-ReinaImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Sophia I ThomopoulosImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.ORCID 0000-0002-0046-4070
Yixue FengImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Robert I ReidDepartment of Radiology, Mayo Clinic, Rochester, MN, United States.ORCID 0000-0003-2391-8650
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, MN, United States.ORCID 0000-0001-7916-622X
Michael W WeinerSchool of Medicine, University of California, San Francisco, CA, United States.
Eleftherios GaryfallidisDepartment of Intelligent Systems Engineering, Indiana University Bloomington, Bloomington, IN, United States.
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Meredith N BraskieImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Sid O'BryantInstitute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.ORCID 0000-0002-4720-8867
Alzheimer’s Disease Neuroimaging Initiative
Health and Aging Brain Study (HABS-HD) Study Team

Funding

The Health & Aging Brain Study - Health Disparities (HABS-HD)U19AG078109 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI LEIGH A JOHNSON, Sid E O'Bryant · 2022 to 2026
$181.1M
Health and Aging Brain among Latino Elders (HABLE-AT(N)) StudyR01AG058533 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JOHNSON, LEIGH A, O'BRYANT, SID E · 2020 to 2025
$45.4M
Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican AmericansR01AG054073 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI O'BRYANT, SID E, TOGA, ARTHUR W · 2017 to 2021
$12.6M
Controlling Quality and Capturing Uncertainty in Advanced Diffusion Weighted MRIR01EB017230 · NIBIB · VANDERBILT UNIVERSITY · PI LANDMAN, BENNETT A. · 2015 to 2024
$5.1M
Epigenetic Risk Factors for AD Age at Onset and Health Disparities: HABLE Epigenetics StudyR01AG070862 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI BARBER, ROBERT CLINTON · 2021 to 2025
$3.4M
CRCNS: Community-supported open-source software for computational neuroanatomyR01EB027585 · NIBIB · TRUSTEES OF INDIANA UNIVERSITY · PI Eleftherios Garyfallidis · 2018 to 2026
$2.6M
FiberNET: Deep learning to evaluate brain tract integrity worldwide and in ADRF1AG057892 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2020 to 2023
$2.6M
Worldwide Tractometry Initiative to Investigate Brain Microstructure, Cognitive Impairment & Dementia in Parkinsons DiseaseRF1NS136995 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA, THOMPSON, PAUL M · 2024 to 2024
$2.2M
Causal and Event Based Modeling of Brain Alterations in ADRDR01AG087513 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Neda Jahanshad · 2025 to 2026
$1.2M
NIA NIH HHS R01 AG054073NIA NIH HHS R01 AG058533NIA NIH HHS R01 AG070862NIA NIH HHS R01 AG087513NIA NIH HHS RF1 AG057892NIA NIH HHS U01 AG068057NIA NIH HHS U19 AG078109NIBIB NIH HHS P41 EB015922NIBIB NIH HHS R01 EB017230NIBIB NIH HHS R01 EB027585NINDS NIH HHS RF1 NS136995
6 · The paper itself

Abstract

Alzheimer's disease (AD) is marked by progressive cognitive decline and memory loss, due to the abnormal accumulation of amyloid-beta (A

Identifiers

PMID40894617
PMCPMC12393426

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.