Evidence map›Paper›PMID 40894614›Full record

ArticlebioRxiv : the preprint server for biology2025

Cerebral blood flow in elastin haploinsufficient and 3xTg-AD mice.

Abigail E Cullen, Emily H Reeve, Nick R Winder, Grant D Henson, Nayantara Arora, Thomas Leonhardt, Ainsley Hogan, Sahana Krishna Kumaran, Naly Setthavonsack, Victoria Krajbich and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Abigail E CullenHuman Physiology, University of Oregon, Eugene, OR, USA.ORCID 0000-0002-0375-9712
Emily H ReeveHuman Physiology, University of Oregon, Eugene, OR, USA.
Nick R WinderHuman Physiology, University of Oregon, Eugene, OR, USA.
Grant D HensonHuman Physiology, University of Oregon, Eugene, OR, USA.
Nayantara AroraHuman Physiology, University of Oregon, Eugene, OR, USA.
Thomas LeonhardtHuman Physiology, University of Oregon, Eugene, OR, USA.
Ainsley HoganHuman Physiology, University of Oregon, Eugene, OR, USA.
Sahana Krishna KumaranHuman Physiology, University of Oregon, Eugene, OR, USA.
Naly SetthavonsackPathology and Laboratory Medicine, School of Medicine, Oregon Health and Science University, Portland, OR, USA.
Victoria KrajbichPathology and Laboratory Medicine, School of Medicine, Oregon Health and Science University, Portland, OR, USA.
Nabil J AlkayedPathology and Laboratory Medicine, School of Medicine, Oregon Health and Science University, Portland, OR, USA.
Martin M PikeBiomedical Engineering, Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, USA.
Randall L WoltjerPathology and Laboratory Medicine, School of Medicine, Oregon Health and Science University, Portland, OR, USA.
Ashley E WalkerHuman Physiology, University of Oregon, Eugene, OR, USA.

Funding

Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Zachary Beattie · 2020 to 2026
$28.6M
Oregon Clinical and Translational Research Institute TL1 ProgramTL1TR002371 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALLISON Deborah FRYER, JESSINA C MCGREGOR · 2017 to 2026
$6.2M
Neuroinflammatory Mechanisms of Vascular Cognitive ImpairmentRF1AG058273 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALKAYED, NABIL J · 2017 to 2023
$4.2M
Large artery stiffness and cerebrovascular dysfunction: Implications for cognitive impairment and neuropathologyR01AG064016 · NIA · UNIVERSITY OF OREGON · PI WALKER, ASHLEY ELIZABETH · 2020 to 2024
$2.3M
NCATS NIH HHS TL1 TR002371NIA NIH HHS P30 AG066518NIA NIH HHS R01 AG064016NIA NIH HHS RF1 AG058273
6 · The paper itself

Abstract

Artery structural properties and Alzheimer's disease (AD) pathology are individually associated with impaired cerebrovascular function; however, the interaction of these factors is unclear. Furthermore, while elastin haploinsufficient (

Indexed as

Alzheimer’s diseasecerebrovascular reactivityelastin haploinsufficiencyneuroinflammation

Identifiers

PMID40894614
PMCPMC12393387

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.