Evidence map›Paper›PMID 40894611›Full record

ArticlebioRxiv : the preprint server for biology2025

Dual S100A1 and ARC gene therapy as a treatment for DMD cardiomyopathy.

David W Hammers, Cora C Hart, Young Il Lee, Margaret M Sleeper, H Lee Sweeney

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

David W HammersDepartment of Pharmacology & Therapeutics and Myology Institute, University of Florida College of Medicine; Gainesville, FL USA.ORCID 0000-0003-2129-4047
Cora C HartDepartment of Pharmacology & Therapeutics and Myology Institute, University of Florida College of Medicine; Gainesville, FL USA.
Young Il LeeDepartment of Pharmacology & Therapeutics and Myology Institute, University of Florida College of Medicine; Gainesville, FL USA.
Margaret M SleeperSmall Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, FL USA.
H Lee SweeneyDepartment of Pharmacology & Therapeutics and Myology Institute, University of Florida College of Medicine; Gainesville, FL USA.

Funding

Understanding and Improving Therapies for the Muscular Dystrophies through Noninvasive BiomarkersP50AR052646 · NIAMS · UNIVERSITY OF FLORIDA · PI JUDGE, ANDREW ROBERT · 2021 to 2024
$6.2M
Understanding the Mechanisms of Fibrosis in Muscular DystrophiesR01AR083108 · NIAMS · UNIVERSITY OF FLORIDA · PI DAVID W HAMMERS · 2023 to 2026
$1.8M
NIAMS NIH HHS P50 AR052646NIAMS NIH HHS R01 AR083108
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is a lethal pediatric striated muscle disease caused by loss of dystrophin for which there is no cure. Cardiomyopathy is the leading cause of death amongst individuals with DMD, and effective therapeutics to treat DMD cardiomyopathy are a major unmet clinical need. This work investigated adeno-associated viral (AAV) gene therapy approaches to treat DMD cardiomyopathy by overexpression of the calcium binding proteins S100A1 and apoptosis repressor with caspase recruitment domains (ARC). Using the severe D2

Indexed as

Biological Sciences- Medical SciencesCalcium handlingCardiomyopathyDuchenne muscular dystrophyGene therapyS100A1

Identifiers

PMID40894611
PMCPMC12393574

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.