Evidence map›Paper›PMID 40894608›Full record

ArticlebioRxiv : the preprint server for biology2025

Intestinal catabolism of dietary fructose promotes obesity and insulin resistance via ileal lacteal remodeling.

Miranda L Lopez, Taekyung Kang, Ana Espeleta, Varvara I Rubtsova, Jongwon Baek, Jakob Songcuan, Elena M Moyer, Joohwan Kim, Won-Suk Song, Sunhee Jung and 18 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors.

Miranda L LopezDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA 92617.
Taekyung KangDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA 92617.
Ana EspeletaMathematical, Computational, and Systems Biology program, University of California Irvine, Irvine, CA 92617.
Varvara I RubtsovaDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA 92617.
Jongwon BaekDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA 92617.
Jakob SongcuanDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA 92617.
Elena M MoyerDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA 92617.
Joohwan KimDepartment of Microbiology and Molecular Genetics, University of California Irvine School of Medicine, Irvine, CA 92617.
Won-Suk SongDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA 92617.
Sunhee JungDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA 92617.
Nicholas D'SaDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA 92617.
Alexis AnicaDepartment of Microbiology and Molecular Genetics, University of California Irvine School of Medicine, Irvine, CA 92617.
Elise TranDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA 92617.
Yujin ChunDepartment of Microbiology and Molecular Genetics, University of California Irvine School of Medicine, Irvine, CA 92617.
Wonsuk ChoiDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA 92617.
Ki-Hong JangDepartment of Microbiology and Molecular Genetics, University of California Irvine School of Medicine, Irvine, CA 92617.
Miranda E KellyDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA 92617.
Ian J TamburiniDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA 92617.
Yasmine H AlamDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA 92617.
Johnny LeDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA 92617.
Cuauhtemoc B RamirezDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA 92617.
Raghu P KataruDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Seon Pyo HongCenter for Vascular Research, Institute for Basic Science, Daejeon, Korea 34141.
Dequina A NicholasDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92617.
Katherine S XueDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92617.
Gina LeeDepartment of Microbiology and Molecular Genetics, University of California Irvine School of Medicine, Irvine, CA 92617.
Hosung BaeDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA 92617.
Cholsoon JangDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA 92617.

Funding

Elucidating dietary fructose and alcohol interactions during liver cancer developmentR01AA029124 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JANG, CHOLSOON · 2021 to 2025
$2.0M
Elucidating alcohol-induced metabolic remodeling of critical organsR21AA030358 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JANG, CHOLSOON, SELDIN, MARCUS MICHAEL · 2023 to 2023
$412k
NIAAA NIH HHS R01 AA029124NIAAA NIH HHS R21 AA030358
6 · The paper itself

Abstract

High-fructose corn syrup (HFCS) consumption is a risk factor for obesity and metabolic syndrome, yet the underlying mechanisms are incompletely understood. Catabolism of dietary fructose primarily occurs in the small intestine and liver, with fructose breakdown in the liver being pathological, while small intestinal fructose clearance protects the liver. Here, we unexpectedly found that inhibition of fructose catabolism specifically in the small intestine mitigates fructose-induced obesity and insulin resistance. Mechanistically, blocking intestinal fructose catabolism reduces dietary fat absorption, which is associated with a decrease in the surface area of the ileal lacteals and alterations in gut microbiome. Fecal transplantation experiments revealed that such a microbiome stimulates the intestine-resident macrophages, promoting lacteal growth and boosting dietary fat absorption. Given the preclinical and clinical studies reporting the effect of fructose catabolism suppression on mitigating diet-induced obesity, our data suggest that such effects are partly mediated by intestinal lacteal remodeling.

Indexed as

Biological SciencesFructoseKetohexokinaseLactealsMicrobiotaObesityPhysiology

Identifiers

PMID40894608
PMCPMC12393376

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.