Evidence map›Paper›PMID 40894563›Full record

ArticlebioRxiv : the preprint server for biology2025

HCN channels reveal conserved and divergent physiology in supragranular pyramidal neurons in primate species.

Cristina Radaelli, Matthew Schmitz, Xiao-Ping Liu, Scott Sawchuk, Ximena Opitz-Araya, Mark Hudson, Naz Taskin, Darren Bertagnolli, Jeff Goldy, Andrew L Ko and 11 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Cristina RadaelliAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-3255-2630
Matthew SchmitzAllen Institute for Brain Science, Seattle, WA 98109, USA.
Xiao-Ping LiuAllen Institute for Brain Science, Seattle, WA 98109, USA.
Scott SawchukAllen Institute for Brain Science, Seattle, WA 98109, USA.
Ximena Opitz-ArayaAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-4960-3622
Mark HudsonDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA 98195, USA.
Naz TaskinAllen Institute for Brain Science, Seattle, WA 98109, USA.
Darren BertagnolliAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-6626-1567
Jeff GoldyAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-5140-6922
Andrew L KoDepartment of Neurological Surgery, University of Washington School of Medicine, Seattle, WA 98195.ORCID 0000-0002-6253-9891
Benjamin L GrannanDepartment of Neurological Surgery, University of Washington School of Medicine, Seattle, WA 98195.
Jason S HauptmanDepartment of Neurological Surgery, University of Washington School of Medicine, Seattle, WA 98195.ORCID 0000-0002-2035-9876
Anoop P PatelDepartment of Neurological Surgery, University of Washington School of Medicine, Seattle, WA 98195.ORCID 0000-0001-7078-9535
Charles CobbsThe Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.ORCID 0000-0001-7688-4293
Kimberly A SmithAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-3142-1970
William J SpainDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA 98195, USA.
Ed S LeinAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-9012-6552
Trygve BakkenAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-3373-7386
Nikolai C DembrowDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-7699-6591
Jonathan T TingAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-8266-0392
Brian E KalmbachAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-3136-8097

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
Cell type selective viral tools to interrogate and correct non-human primate and human brain circuitryUG3MH120095 · NIMH · ALLEN INSTITUTE · PI KALUME, FRANCK K, LEIN, ED · 2020 to 2022
$3.8M
Multimodal analysis of primate infragranular pyramidal neurons and their modulationR01NS123959 · NINDS · ALLEN INSTITUTE · PI DEMBROW, NIKOLAI C, KALMBACH, BRIAN E. · 2021 to 2025
$2.8M
NIH HHS P51 OD010425NIMH NIH HHS UG3 MH120095NINDS NIH HHS R01 NS123959
6 · The paper itself

Abstract

The physiological properties of human and rodent neurons differ, yet the extent to which these differences reflect human specializations is often unclear. Compared with their rodent counterparts, human supragranular pyramidal neurons possess enriched HCN-channel-dependent intrinsic membrane properties and a related sensitivity to synaptic inputs containing delta/theta band frequencies. We tested whether other primate species possess enriched HCN-channel dependent membrane properties. We found ubiquitous

Identifiers

PMID40894563
PMCPMC12393543

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.