Evidence map›Paper›PMID 40894544›Full record

ArticlebioRxiv : the preprint server for biology2025

A Spatially Coordinated Keratinocyte-Fibroblast Circuit Recruits MMP9

Yuqing Wang, Khashayar Afshari, Nazgol-Sadat Haddadi, Carolina Salomão Lopes, Chee-Huat Linus Eng, Nuria Martinez, Leah Whiteman, Ksenia S Anufrieva, Kevin Wei, Kirsten Frieda and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Yuqing WangDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School.
Khashayar AfshariDepartment of Dermatology, University of Massachusetts Chan Medical School.
Nazgol-Sadat HaddadiDepartment of Dermatology, University of Massachusetts Chan Medical School.
Carolina Salomão LopesDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School.
Chee-Huat Linus EngSpatial Genomics.
Nuria MartinezDepartment of Dermatology, University of Massachusetts Chan Medical School.
Leah WhitemanDepartment of Medicine, University of Massachusetts Chan Medical School.
Ksenia S AnufrievaDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital at Harvard Medical School.
Kevin WeiDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital at Harvard Medical School.
Kirsten FriedaSpatial Genomics.
Stefania GallucciDepartment of Medicine, University of Massachusetts Chan Medical School.
Misha RosenbachDepartment of Dermatology, University of Pennsylvania.
Ruth Ann VleugelsDepartment of Dermatology, Brigham and Women's Hospital at Harvard Medical School.
John E HarrisDepartment of Dermatology, University of Massachusetts Chan Medical School.
Mehdi RashighiDepartment of Dermatology, University of Massachusetts Chan Medical School.ORCID 0000-0002-9170-5887
Manuel GarberDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School.ORCID 0000-0001-8732-1293

Funding

P50-Admin Core-Harris/GarbP50AR080593 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI John E Harris · 2022 to 2026
$9.2M
Predictive drivers of new onset, relapse, and progression of human autoimmunity in skinU01AI176310 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Manuel Garber, John E Harris · 2023 to 2026
$5.3M
Pathogenic fibroblast differentiation in rheumatoid arthritisK08AR077037 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI WEI, KEVIN S · 2020 to 2024
$799k
NIAID NIH HHS U01 AI176310NIAMS NIH HHS K08 AR077037NIAMS NIH HHS P50 AR080593
6 · The paper itself

Abstract

Photosensitivity is a hallmark of cutaneous lupus erythematosus (CLE) and dermatomyositis (DM), yet the mechanisms linking ultraviolet B (UVB) exposure to tissue-specific autoimmunity remain incompletely defined. Here, we use an integrative human-based approach, including single-cell RNA sequencing, spatial transcriptomics (seqFISH+), in vivo UVB provocation, and in vitro modeling, to uncover a spatially coordinated inflammatory circuit that underlies interferon-I (IFN-I)-amplified skin pathology. We identify MMP9

Identifiers

PMID40894544
PMCPMC12393449

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.