Evidence map›Paper›PMID 40894531›Full record

ArticlebioRxiv : the preprint server for biology2025

Autosomal Allelic Inactivation: Variable Replication and Dosage Sensitivity.

Michael B Heskett, Athanasios E Vouzas, Brian Johnstone, Krister P Freese, Phillip A Yates, Philip F Copenhaver, Paul T Spellman, David M Gilbert, Mathew J Thayer

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Michael B HeskettDivision of Hematology Oncology, Departments of Medicine and Human Genetics, David Geffen School of Medicine, University of California, Los Angeles.
Athanasios E VouzasSan Diego Biomedical Research Institute, 3525 John Hopkins Court, San Diego, CA 92121.
Brian JohnstoneShriners Hospitals for Children-Portland, 3101 SW Sam Jackson Park Rd, Portland, Oregon, 97239.
Krister P FreeseDepartment of Orthopedics and Rehabilitation.
Phillip A YatesDepartment of Chemical Physiology and Biochemistry.
Philip F CopenhaverDepartment of Cell, Developmental and Cancer Biology, Oregon Health & Science University, 3181 S. W. Sam Jackson Park Road, Portland, Oregon 97239.ORCID 0000-0003-0918-3264
Paul T SpellmanDivision of Hematology Oncology, Departments of Medicine and Human Genetics, David Geffen School of Medicine, University of California, Los Angeles.ORCID 0000-0002-4810-0022
David M GilbertSan Diego Biomedical Research Institute, 3525 John Hopkins Court, San Diego, CA 92121.ORCID 0000-0001-8087-9737
Mathew J ThayerDepartment of Chemical Physiology and Biochemistry.ORCID 0000-0001-6483-1661

Funding

Genome Plasticity during ES Cell Differentiation to Neural LineagesR01GM083337 · NIGMS · SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE · PI David M Gilbert · 2007 to 2026
$6.1M
The role of ASARs in chromosome dynamicsR01GM130703 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI THAYER, MATHEW J · 2019 to 2022
$1.2M
Allelic Expression Imbalance in Trisomy 21RF1NS142814 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI THAYER, MATHEW J · 2025 to 2025
$780k
Integrative Analysis of DNA Replication Timing in CancerK00CA245677 · NCI · STANFORD UNIVERSITY · PI HESKETT, MICHAEL B · 2022 to 2024
$255k
NCI NIH HHS K00 CA245677NIGMS NIH HHS R01 GM083337NIGMS NIH HHS R01 GM130703NINDS NIH HHS RF1 NS142814
6 · The paper itself

Abstract

Autosomal monoallelic gene expression and asynchronous replication between alleles are well-established features of imprinted genes and genes regulated by allelic exclusion. Inactivation/Stability Centers (I/SCs) are recently described autosomal loci that exhibit epigenetic regulation of allelic expression and replication timing, with differences that can be comparable to those observed between the active and inactive X chromosomes

Identifiers

PMID40894531
PMCPMC12393279

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.