ArticleInternational journal of general medicine2025
Vaginal Microecology Disturbance and Immune Dysregulation Are Associated with Human Papillomavirus Infection: Insights from a Two-year Study of Vaginal Microecology.
Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Identification of key vaginal microbial signatures and immune remodeling associated with HR-HPV clearance following Kushen Gel treatment: a longitudinal analysis.Frontiers in medicine · 2026Article
- Morphology-defined bacterial vaginosis and HPV-related cervical screening abnormalities: a two-year real-world study with histopathologic correlation.Frontiers in cellular and infection microbiology · 2026Article
- HPV vaccination associates withFrontiers in microbiology · 2026Article
- The implications and mechanisms of vaginal microbiota metabolites on cervical cancer progression.Frontiers in cellular and infection microbiology · 2026Review
- Understanding the role of oral and vaginal microbiomes in HPV-related cervical, head, and neck cancers: knowledge gaps and feasibility in Sub-Saharan Africa.Frontiers in microbiomes · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Human papillomavirus (HPV) infection is essential for cervical cancer (CC) development, yet only a fraction of infections persist and progress. Vaginal microecology and immune responses may play pivotal roles in determining HPV outcomes. This study aimed to explore the association between vaginal microecological alterations, immune-inflammatory markers, and the natural course of HPV infection. Methods: We retrospectively analyzed 312 women undergoing HPV genotyping, vaginal microecological evaluation, and cytokine profiling over a two-year period. Logistic regression and ROC curve analyses were used to identify predictors of HPV persistence or clearance. Results: HPV-positive women exhibited significantly higher rates of elevated vaginal pH (76.2%), bacterial vaginosis (37.1%), reduced hydrogen peroxide production (41.0%), sialidase activity (33.3%), and Community state type IV (CST IV) dominance (34.3%) compared to HPV-negative women (P<0.001). Multivariate analysis revealed elevated pH, Nugent score ≥ 7, negative H Conclusion: Vaginal microecological imbalance and immune dysregulation are major determinants of HPV persistence. Comprehensive assessment of these factors may improve risk stratification and guide individualized interventions for HPV-infected women.
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Registered trials
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