Evidence map›Paper›PMID 40894432›Full record

ArticleJournal of neurological surgery. Part B, Skull base2025

Prevalence and Impact of Constipation on Reconstructive Outcomes Following Endoscopic Skull Base Surgery.

Theodore V Nguyen, Ellen M Hong, Benjamin F Bitner, Michelle Chernyak, Daniella Chan, Katelyn K Dilley, Arash Abiri, Ji Y Li, Sina J Torabi, Jonathan C Pang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurological surgery. Part B, Skull base, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Theodore V NguyenDepartment of Otolaryngology - Head and Neck Surgery, University of California, Irvine, Orange, California, United States.
Ellen M HongDepartment of Otolaryngology - Head and Neck Surgery, University of California, Irvine, Orange, California, United States.
Benjamin F BitnerDepartment of Otolaryngology - Head and Neck Surgery, University of California, Irvine, Orange, California, United States.
Michelle ChernyakDepartment of Otolaryngology - Head and Neck Surgery, University of California, Irvine, Orange, California, United States.
Daniella ChanDepartment of Otolaryngology - Head and Neck Surgery, University of California, Irvine, Orange, California, United States.
Katelyn K DilleyDepartment of Otolaryngology - Head and Neck Surgery, University of California, Irvine, Orange, California, United States.
Arash AbiriDepartment of Otolaryngology - Head and Neck Surgery, University of California, Irvine, Orange, California, United States.
Ji Y LiDepartment of Otolaryngology - Head and Neck Surgery, University of California, Irvine, Orange, California, United States.
Sina J TorabiDepartment of Otolaryngology - Head and Neck Surgery, University of California, Irvine, Orange, California, United States.
Jonathan C PangDepartment of Otolaryngology - Head and Neck Surgery, University of California, Irvine, Orange, California, United States.ORCID 0000-0002-2300-3904
Frank P K HsuDepartment of Otolaryngology - Head and Neck Surgery, University of California, Irvine, Orange, California, United States.
Edward C KuanDepartment of Otolaryngology - Head and Neck Surgery, University of California, Irvine, Orange, California, United States.ORCID 0000-0003-3475-0718

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Postoperative constipation in endoscopic skull base surgery (ESBS) may provoke undesired straining, which, in theory, may create intracranial pressure shifts and impact skull base reconstruction. The purpose of this study is to assess the prevalence and contributing factors to postoperative constipation after ESBS, and whether this impacts reconstructive outcomes. Methods: Patients undergoing ESBS between July 2018 and December 2022 at a single-center, tertiary academic skull base surgery program were retrospectively reviewed. Chart reviews were performed to identify average bowel movements per day, indication for surgery, age, sex, body mass index (BMI), history of chronic pain, length of postoperative bedrest, length of stay (LOS), and postoperative use of opioid analgesics. Additionally, use of a standing stool bowel regimen, as-needed (PRN) stool softeners/laxatives, and enemas were recorded. Constipation was defined as greater than 48 hours without a bowel movement. Results: In total, 213 patients (115 with intradural pathologies) were identified, of which 146 (69%) patients had postoperative constipation. Postoperative constipation was associated with longer bedrest (1.86 ± 0.20 vs. 1.06 ± 0.12 days; Conclusion: Postoperative constipation rates were high after ESBS and likely causative factors include increased immobilization and postoperative opioid use. Standing bowel regimens should be considered in ESBS patients. However, there was no increased rate of postoperative CSF leaks.

Indexed as

analgesiaconstipationCSF leakopioidpostoperativeskull base reconstruction outcomes

Identifiers

PMID40894432
PMCPMC12396863

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.