Evidence map›Paper›PMID 40894423›Full record

ArticleJournal of neurological surgery. Part B, Skull base2025

International, Multi-Institutional Evaluation of Practice Patterns and Outcomes for Recurrent and Metastatic Sinonasal Undifferentiated Carcinoma.

Anirudh Saraswathula, Mohammed N Ullah, Jacklyn Liu, Yoko Takahashi, Arushi Mahajan, Simonetta Battocchio, Paolo Bossi, Paolo Castelnuovo, Carla Facco, Marco Ferrari and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurological surgery. Part B, Skull base, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Anirudh SaraswathulaDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Mohammed N UllahDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0003-3263-983X
Jacklyn LiuUCL Cancer Institute, University College London and Head and Neck Centre, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Yoko TakahashiDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States.
Arushi MahajanDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, United States.
Simonetta BattocchioDepartment of Molecular and Translational Medicine, University of Brescia, ASST Spedali Civili, Brescia, Italy.
Paolo BossiDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Paolo CastelnuovoUnit of Otorhinolaryngology - Head and Neck Surgery, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
Carla FaccoUnit of Pathology, ASST Sette Laghi, University of Insubria, Varese, Italy.
Marco FerrariSection of Otorhinolaryngology - Head and Neck Surgery, Department of Neurosciences, University of Padova, Padova, Italy.ORCID 0000-0002-4023-0121
Dawn CarnellUCL Cancer Institute, University College London and Head and Neck Centre, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Martin D ForsterUCL Cancer Institute, University College London and Head and Neck Centre, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Alessandro FranchiDepartment of Translational Research, University of Pisa, Pisa, Italy.
Amrita JayDepartment of Histopathology, University College London Hospitals NHS Trust, London, United Kingdom.
Davide LombardiUnit of Otorhinolaryngology - Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
Valerie J LundRoyal National Ear, Nose, Throat and Eastman Dental Hospital, University College London Hospitals NHS Trust, London, United Kingdom.
Davide MattavelliUnit of Otorhinolaryngology - Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
Piero NicolaiSection of Otorhinolaryngology - Head and Neck Surgery, Department of Neurosciences, University of Padova, Padova, Italy.
Vittorio RampinelliUnit of Otorhinolaryngology - Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
Fausto SessaUnit of Pathology, ASST Sette Laghi, University of Insubria, Varese, Italy.
Shirley Y SuDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States.
Mario Turri-ZanoniUnit of Otorhinolaryngology - Head and Neck Surgery, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
Laura ArdighieriDepartment of Molecular and Translational Medicine, University of Brescia, ASST Spedali Civili, Brescia, Italy.
Erin McKeanDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, United States.
Matt LechnerUCL Cancer Institute, University College London and Head and Neck Centre, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Ehab HannaDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States.
Nyall R LondonDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.

Funding

RESEARCH TRAINING IN OTOLARYNGOLOGYT32DC000027 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI CAREY, JOHN PATRICK · 1989 to 2023
$5.5M
NIDCD NIH HHS T32 DC000027
6 · The paper itself

Abstract

Objectives: The aims of this study were to analyze the clinical characteristics of patients with recurrent and metastatic sinonasal undifferentiated carcinoma (SNUC) and evaluate the current treatment strategies to help guide future management. Design: This is a retrospective cohort study. Setting: The study was conducted at six international tertiary treatment centers. Participants: Patients with documented diagnoses of recurrent or metastatic SNUC since 1983 were included in the study. Main Outcome Measures: Patient demographics and clinical characteristics were collected. Primary outcome measures included disease-specific survival (DSS), overall survival (OS), and time to recurrence (TTR) following initial treatment. Further univariable and multivariable analyses were performed to assess for prognostic factors. Results: A total of 97 patients with a mean (standard deviation [SD]) age of 52.4 (15.6) were identified, 15 of whom presented with metastatic SNUC and 90 of whom developed recurrence. Management in both populations was widely variable. For patients with metastatic disease, the 1-year DSS probability was 33.3% (95% confidence interval [CI], 10.8-100%). For patients with recurrent SNUC, the 1- and 5-year DSS probabilities were 45.7% (95% CI, 31.9-65.6%) and 8.6% (95% CI, 2.9-25.3%), respectively. The median (interquartile range [IQR]) TTR was 8 months (3-18.5 months). Multivariable analyses revealed a significant association between orbital involvement on initial presentation and TTR (hazard ratio [HR] = 3.28; 95% CI, 1.45-7.42; Conclusions: To our knowledge, this is the first study addressing metastatic and recurrent SNUC based on a large patient cohort. Orbital extension of the primary SNUC may predict a higher probability of recurrence following treatment, suggesting the possible utility of a more aggressive treatment in this subgroup of patients. A heterogenous patient population and wide variability in management emphasize the challenges in standardizing care; however, dismal survival rates demonstrate the necessity for further evaluation of current approaches to improve evidence-based recommendations.

Indexed as

chemoradiationmetastaticorbital extensionrecurrencesinonasal undifferentiated carcinoma

Identifiers

PMID40894423
PMCPMC12396877

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.