ArticlePhysics and imaging in radiation oncology2025
Exploring hypoxia in head and neck cancer through blood perfusion and metabolism using dual-energy computed tomography and positron emission tomography.
Article in Physics and imaging in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and purpose: Hypoxia for head and neck cancer (HNC) can be imaged with positron emission tomography (PET) using Materials and methods: Corresponding DECT, FAZA, and FDG PET/CT for 6 HNC patients before and during RT were acquired. A FAZA tumor-to-muscle (TMR) ratio ≥1.2 was used for hypoxic classification. Within the gross tumor volume (GTV), the IC standard deviation over mean ratio, Results: ROC curves improved with AUC around 0.9 when combining the blood perfusion and metabolism metrics. GTVs with high metabolic activity and and low modelled blood perfusion was dominated by hypoxic fractions >0.75 supporting the CSH model. Conclusions: Combining blood perfusion and metabolism modelled from DECT and FDG PET derived metrics resulted in a superior predictive power as potential hypoxia biomarkers which might be explained by a CSH model.
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