Evidence map›Paper›PMID 40894246›Full record

ArticleOrthopedic reviews2025

Preoperative strategies to prevent periprosthetic joint infection after knee replacement: evidence-based recommendations for multidisciplinary practice.

Hassan Zmerly, Ibrahim Akkawi, Manuela Moscato, Riccardo Galletti, Valentina Di Gregori, Francesco Pegreffi

Abstract read
In one paragraph

Article in Orthopedic reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hassan ZmerlyDepartment for Life Quality Studies University of Bologna.ORCID https://orcid.org/0000-0003-3353-1759
Ibrahim AkkawiOrthopedics Villa Erbosa, GSD, Bologna, Italy.ORCID https://orcid.org/0000-0003-3972-5968
Manuela MoscatoOrthopedics San Pier Damiano Hopistal, GVM.
Riccardo GallettiInternal Medecin San Pier Damiano Hospital, GVM.
Valentina Di GregoriHealth Management San Pier Damiano Hospital, GVM.ORCID https://orcid.org/0000-0003-3065-5537
Francesco PegreffiDepartment of Medicine and Surgery Università degli Studi di Enna Kore.ORCID https://orcid.org/0000-0002-6788-6040

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periprosthetic joint infection (PJI) is a severe and challenging complication following joint replacement that significantly impacts patient outcomes and implant longevity. Various factors contribute to PJI onset, including patient-related comorbidities and surgical procedures. Preventive strategies are categorized into preoperative, perioperative, and postoperative measures. Preoperative risk factors can be classified as general or local. General ones include comorbidity management (metabolic disorder, rheumatic and inflammatory diseases), nutritional optimization, weight control, bacterial decolonization, and lifestyle modifications. Local factors involve avoiding intra-articular injections before surgery and assessing previous knee interventions, in addition to implementing preoperative physiotherapy and ensuring proper skin preparation. Preoperative patient optimization significantly improves outcomes following knee replacement by reducing PJI risk, as well as hospital stays and recovery times. Implementing standardized, evidence-based preoperative strategies can enhance surgical success and long-term implant survival. Multidisciplinary collaboration between surgeons, general practitioners, and healthcare providers is essential to minimize infection risks and improve patient outcomes following joint replacement. This paper focuses on preoperative optimization, highlighting evidence-based recommendations to minimize the risk of PJI in patients undergoing knee replacement.

Indexed as

bacterial decolonizationjoint replacementknee replacementPeriprosthetic joint infectionprevention

Identifiers

PMID40894246
PMCPMC12399268

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.