ReviewCurrent research in physiology2025
High-intensity training and irisin response: A possible molecular cross-talk for irisin response.
Review in Current research in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- High-Intensity Exercise Performance as a Complex Adaptive System: An Integrative Review.Muscles (Basel, Switzerland) · 2026Review
- Myosteatosis: Epidemiological Insights, Functional Decline, and Diagnostic Advances.Current obesity reports · 2025Review
- Comparison of Acute Irisin and Cognitive Responses to Different Exercise Modalities Among Late Adolescents.Healthcare (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical exercise is widely recognized for its positive effect on health through alterations in genetic, molecular, or tissue-level pleiotropic effects. The extent of these advantages hinges on the intensity that elicits optimal threshold adaptation, facilitating interactions and communication within or between the cells. This requires the activation of several proteins, enzymes, and hormones. Irisin, an exercise-triggered hormone, is pivotal in converting white fat into brown fat, enhancing bone health, and optimizing brain functions. The activation of irisin is contingent upon precise exercise protocols that trigger several molecular cross-talks. However, no specific exercise protocols (types/intensity/duration) have been developed. Therefore, establishing specific exercise protocols could reveal irisin-induced benefits on bone and brain health. The present review discussed how high-intensity training (HIT) triggers the irisin response by activating its upstream and downstream molecular signaling pathways and how HIT helps to cross-talk these signaling pathways to improve irisin response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.