ArticleFrontiers in pharmacology2025
Population-specific genetic differences of acute coronary syndrome in Han and Uyghur Chinese.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Comments on: "Association of Clopidogrel Genetic Polymorphism With Efficacy and Safety for Ischemic Stroke or Transient Ischemic Attack: A Systematic Review and Updated Meta-Analysis".Journal of clinical neurology (Seoul, Korea) · 2026Article
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12 authors.
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Abstract
Background: Acute coronary syndrome (ACS) is a critical cardiovascular condition with diverse clinical presentations, necessitating personalized therapeutic approaches. This study explores the genetic variation associated with ACS subtypes in the Han and Uyghur Chinese populations to support the development of precision medicine approaches tailored to ethnic-specific genetic backgrounds. Methods: A total of 985 ACS patients (668 Han and 317 Uyghur Chinese) representing different ACS subtypes were enrolled. Clinical characteristics and 66 genetic polymorphisms were analyzed. Statistical analyses were conducted to identify differences in genetic variants and clinical features across ACS subtypes and ethnic groups. Results: Significant clinical and genetic differences were observed between ACS subtypes and between ethnic groups. In the Han population, polymorphisms in Conclusion: This study highlights ethnic differences in the genetic architecture of ACS. The result also underscores the need for population-specific strategies in risk stratification and treatment. The identified genetic markers and predictive models may guide future research on ethnicity-specific risk stratification.
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