Evidence map›Paper›PMID 40894201›Full record

ArticleFrontiers in pharmacology2025

Menthol-thymol NADES as a fungicidal and chemosensitizing agent against multidrug-resistant

Melisa Fabiana Negro, Pamela Soledad Bustos, Lautaro Bellezze, María Gabriela Ortega, Javier Echeverría, María Fernanda Silva, Mariana Andrea Peralta

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Melisa Fabiana NegroFarmacognosia, Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Pamela Soledad BustosFarmacognosia, Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Lautaro BellezzeFarmacognosia, Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
María Gabriela OrtegaFarmacognosia, Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Javier EcheverríaDepartamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.
María Fernanda SilvaGrupo de Química Analítica Verde (GQAV), Instituto de Biología Agrícola de Mendoza (IBAM-CONICET). Facultad de Ciencias Agrarias-Universidad Nacional de Cuyo (FCA-UNCuyo), Mendoza, Argentina.
Mariana Andrea PeraltaFarmacognosia, Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The increasing prevalence of azole-resistant Purpose: This study evaluated a eutectic system composed of menthol and thymol (MT NADES, 1:1 M ratio) for its antifungal efficacy against a multidrug-resistant clinical Materials and methods: The antifungal activity of MT NADES was evaluated against a clinical Results and discussion: MT NADES demonstrated potent fungicidal activity against resistant Conclusion: These findings underscore the therapeutic potential of menthol-thymol NADES as a multifunctional, plant-derived antifungal strategy capable of overcoming multidrug resistance mechanisms and potentiating azole efficacy in

Indexed as

antifungalCandida albicanschemosensitizerecopharmacognosyefflux pump inhibitionmultidrug resistancenatural deep eutectic solventsterpenes

Identifiers

PMID40894201
PMCPMC12394468

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.