ArticleFrontiers in pharmacology2025
Kangshujiangu granules improve NAFLD via cross-organ autophagy activation shared with osteoporosis.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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8 authors.
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Abstract
Background: Osteoporosis (OP), an age-related skeletal disorder characterized by reduced bone mass and deteriorated microarchitecture, and non-alcoholic fatty liver disease (NAFLD), a metabolic condition primarily driven by obesity and insulin resistance (with age as a modifying factor), were investigated in this study. We aimed to elucidate the correlation between OP and NAFLD-associated lipid metabolism, and determine the therapeutic effects and molecular mechanisms of Kangshujiangu granules (KSJG) on NAFLD pathogenesis. Methods: Clinical study: 261 patients were stratified by OP T-scores into OP and non-OP groups. Bone density, lipid profiles, and liver function were analyzed for NAFLD-OP correlations. Results: Clinical findings: Osteoporosis prevalence exhibited age-dependent elevation. Age, BMI, TC, and TG as independent risk factors for OP ( Conclusion: OP exhibited a negative correlation with lipid metabolism indexes of NAFLD. Bilateral ovariectomy (OVX) simultaneously induced OP and NAFLD, while KSJG granules ameliorated lipid dysregulation via autophagy modulation. KSJG granules enhanced autophagy activation through the AMPK/ULK1 (Ser555) pathway, thereby alleviating NAFLD-associated lipid metabolic disturbances.
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