ArticlemedRxiv : the preprint server for health sciences2025
Retinal Cytoarchitectural Alterations Across the Psychosis Spectrum and Their Correlates with Cognition: A UK Biobank Nested Case-Control Study.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Retinal structure may serve as a biomarker for psychosis-spectrum disorders (PSD) and cognition, but larger, well-controlled and detailed studies are needed. This study investigates retinal thickness differences and their association with cognition in PSD (including schizophrenia, bipolar disorder, and major depression with psychosis) compared to age-, sex-matched healthy controls (HC). In this nested case-control study using the UK Biobank data, 476 participants underwent macular optical coherence tomography (OCT). Repeated-measures ANCOVA assessed retinal thickness across two measures (left/right eyes) and two groups (PSD/HC). Comprehensive analyses were conducted, accounting for various sociodemographic (ethnicity, area-level deprivation, etc); ocular (visual acuity, intraocular pressure, etc); and health (blood pressure, body mass index) covariates, as well as excluding individuals with cardiometabolic conditions. Layers were evaluated to determine their relationship with cognition. Thinner maculae (
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